Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?
Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?
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DOI：
10.1186/s40662-016-0048-4
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Elsheikh A
中科院分区：
文献类型：
--
作者：
Bao F;Geraghty B;Wang Q;Elsheikh A
圆锥角膜是一种双侧、非炎症性、退行性角膜疾病。圆锥角膜的发生和发展与角膜变薄和圆锥突起有关，导致不规则散光。随着胶原组织的破坏，角膜失去其形状和功能，导致进行性视觉退化。目前，角膜地形图是诊断圆锥角膜最重要的工具，这可能会导致亚临床期患者群体中的假阴性。然而，现在的假设是，角膜的生物力学失稳可能发生在圆锥角膜的地形图证据之前，因此可能有助于疾病的诊断和治疗。本文从角膜生物力学的角度对圆锥角膜的定义、诊断和治疗策略进行了综述。
Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography is the most important tool for the diagnosis of keratoconus, which may lead to false negatives among the patient population in the subclinical phase. However, it is now hypothesised that biomechanical destabilisation of the cornea may take place ahead of the topographic evidence of keratoconus, hence possibly assisting with disease diagnosis and management. This article provides a review of the definition, diagnosis, and management strategies for keratoconus based on corneal biomechanics.