Liver-resident NK cells and their potential functions
Liver-resident NK cells and their potential functions
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肝脏驻留 NK 细胞及其潜在功能
DOI：
10.1038/cmi.2017.72
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发表时间：
2017
影响因子：
24.1
通讯作者：
Sun Rui
中科院分区：
文献类型：
--
作者：
Peng Hui;Sun Rui
自然杀伤(NK)细胞是一类具有不同表型和功能亚群的异质性天然淋巴细胞。特别是，最近的研究发现，肝脏中存在一种独特的NK细胞亚群，它们以组织驻留细胞的形式存在，提供抗原特异性的记忆反应，并表现出与传统的NK(CNK)细胞不同的表型和发育特征。这些发现鼓励研究人员在其他地方发现组织驻留的NK细胞，详细的分析表明，这些组织驻留的NK细胞与肝脏驻留的NK细胞和组织驻留的记忆T细胞有许多相似之处。在这里，我们简要回顾了肝脏NK细胞的发现，并讨论了它们与CNK细胞和其他新出现的NK细胞亚群的关系以及它们的潜在功能。
Natural killer (NK) cells represent a heterogeneous population of innate lymphocytes with phenotypically and functionally distinct subsets. In particular, recent studies have identified a unique subset of NK cells residing within the liver that are maintained as tissue-resident cells, confer antigen-specific memory responses and exhibit different phenotypical and developmental characteristics compared with conventional NK (cNK) cells. These findings have encouraged researchers to uncover tissue-resident NK cells at other sites, and detailed analyses have revealed that these tissue-resident NK cells share many similarities with liver-resident NK cells and tissue-resident memory T cells. Here, we present a brief historical perspective on the discovery of liver-resident NK cells and discuss their relationship to cNK cells and other emerging NK cell subsets and their potential functions.