Outcomes of colon resection in patients with metastatic colon cancer
Outcomes of colon resection in patients with metastatic colon cancer
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DOI：
10.1016/j.amjsurg.2016.01.025
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发表时间：
2016-08-01
影响因子：
3
通讯作者：
Carmichael, Joseph C.
中科院分区：
文献类型：
--
作者：
Moghadamyeghaneh, Zhobin;Hanna, Mark H.;Carmichael, Joseph C.
背景：晚期结直肠癌患者术后并发症发生率高。我们试图通过癌症stage.METHODS：国家手术质量改进计划数据库来评估2012年至2014年所有诊断为结肠癌的结肠切除术患者的结果。进行多变量逻辑回归分析，按癌症分期调查患者结局。结果：共确定了7，786例接受结肠切除术的结肠癌患者。其中，10.8%在手术时有转移。转移性疾病患者的围手术期发病率（校正比值比[AOR]：1.44，P = 0.01）和死亡率（AOR：3.72，P = 0.01）风险显著增加。转移性疾病患者明显年轻（AOR：0.99，P <0.01），美国麻醉医师学会评分较高（AOR：1.29，P <0.2），急诊手术率较高（AOR：1.40，P <0.01）。术后发病率和死亡率明显高于局限性疾病患者。爱思唯尔公司出版
BACKGROUND: Patients with advanced colorectal cancer have a high incidence of postoperative complications. We sought to identify outcomes of patients who underwent resection for colon cancer by cancer stage.METHODS: The National Surgical Quality Improvement Program database was used to evaluate all patients who underwent colon resection with a diagnosis of colon cancer from 2012 to 2014. Multivariate logistic regression analysis was performed to investigate patient outcomes by cancer stage.RESULTS: A total of 7,786 colon cancer patients who underwent colon resection were identified. Of these, 10.8% had metastasis at the time of operation. Patients with metastatic disease had significantly increased risks of perioperative morbidity (adjusted odds ratio [AOR]: 1.44, P = .01) and mortality (AOR: 3.72, P = .01). Patients with metastatic disease were significantly younger (AOR: .99, P < .01) had a higher American Society of Anesthesiologists score (AOR: 1.29, P < .2) and had a higher rate of emergent operation (AOR: 1.40, P < .01).CONCLUSIONS: Overall, 10.8% of patients undergoing colectomyfor colon cancer have metastatic disease. Postoperative morbidity and mortality are significantly higher than in patients with localized disease. Published by Elsevier Inc.