Quantifying dermal microcirculatory changes of neuropathic and neuroischemic diabetic foot ulcers using spatial frequency domain imaging: a shade of things to come?
Quantifying dermal microcirculatory changes of neuropathic and neuroischemic diabetic foot ulcers using spatial frequency domain imaging: a shade of things to come?
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DOI：
10.1136/bmjdrc-2020-001815
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发表时间：
2020-11
影响因子：
4.1
通讯作者：
Armstrong DG
中科院分区：
文献类型：
--
作者：
Murphy GA;Singh-Moon RP;Mazhar A;Cuccia DJ;Rowe VL;Armstrong DG
非侵入性血管和灌注诊断技术的应用是评估糖尿病患者下肢溃疡和截肢风险的重要组成部分。检测糖尿病患者微血管扩张功能受损的方法可能有可能在临床可识别的体征之前识别有溃疡风险的部位。空间频域成像(SFDI)使用图案化的近红外和可见光光谱来确定组织氧饱和度和真皮浅层和深层的血红蛋白分布，显示在神经病理性和神经缺血性溃疡之前发生的明显微循环和氧合变化。对35例有糖尿病足溃烂病史的糖尿病患者每月进行SFDI成像。在长达一年的纵向研究中，选择了两名溃烂的患者与来自SFDI的真皮微循环生物标记物一起展示他们的临床过程。患者1在3个月前出现神经病理性溃疡，表现为局部组织氧饱和度升高和浅表乳头状血红蛋白浓度降低。患者2出现双侧神经缺血性溃疡，表现为组织氧饱和度降低，浅乳头状和真皮深层网状血红蛋白浓度升高。不同病因的创面在肉眼溃烂前表现出独特的真皮微循环变化。在从SFDI开发预测模型之前，生物标记物数据必须与纵向追踪时溃烂的患者的临床病程相关。NCT03341559。
The use of non-invasive vascular and perfusion diagnostics are an important part of assessing lower extremity ulceration and amputation risk in patients with diabetes mellitus. Methods for detecting impaired microvascular vasodilatory function in patients with diabetes may have the potential to identify sites at risk of ulceration prior to clinically identifiable signs. Spatial frequency domain imaging (SFDI) uses patterned near-infrared and visible light spectroscopy to determine tissue oxygen saturation and hemoglobin distribution within the superficial and deep dermis, showing distinct microcirculatory and oxygenation changes that occur prior to neuropathic and neuroischemic ulceration. 35 patients with diabetes mellitus and a history of diabetic foot ulceration were recruited for monthly imaging with SFDI. Two patients who ulcerated during the year-long longitudinal study were selected for presentation of their clinical course alongside the dermal microcirculation biomarkers from SFDI. Patient 1 developed a neuropathic ulcer portended by a focal increase in tissue oxygen saturation and decrease in superficial papillary hemoglobin concentration 3 months prior. Patient 2 developed bilateral neuroischemic ulcers showing decreased tissue oxygen saturation and increased superficial papillary and deep dermal reticular hemoglobin concentrations. Wounds of different etiology show unique dermal microcirculatory changes prior to gross ulceration. Before predictive models can be developed from SFDI, biomarker data must be correlated with the clinical course of patients who ulcerate while being followed longitudinally. NCT03341559.
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影响因子：
16.2
作者：
Waaijman, Roelof;de Haart, Mirjam;Bus, Sicco A.
通讯作者：
Bus, Sicco A.
影响因子：
4.3
作者：
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影响因子：
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作者：
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DOI：
10.7547/87507315-80-6-307
发表时间：
1990-06-01
影响因子：
0.7
作者：
BOYD, RB;BURKE, JP;NUGENT, JF
通讯作者：
NUGENT, JF
影响因子：
2.1
作者：
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通讯作者：
Yue, DK