EPR dose reconstruction for bone-seeking 90Sr
EPR dose reconstruction for bone-seeking 90Sr
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DOI：
10.1016/s0969-8043(98)00133-x
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发表时间：
1999-08-01
影响因子：
1.6
通讯作者：
Romanyukha, AA
中科院分区：
文献类型：
--
作者：
Ignatiev, EA;Lyubashevskii, NM;Romanyukha, AA
本文报道了用~（90）Sr对狗钙化组织进行EPR剂量重建的结果。已经确定，在口腔中对称位置的牙齿的牙齿组织中吸收的剂量值没有本质差异，而在非对称位置的牙齿中吸收剂量值出现显著差异。在90 Sr内照射的情况下，牙冠牙本质中的剂量重建起着重要的作用。发现其量与股骨干皮质骨剂量、骨内膜骨表面剂量和股骨脂肪骨髓剂量接近。这些数值超过了牙釉质吸收的剂量，这一事实表明了内照射的主要作用。在干骺端骨小梁股骨、牙槽骨壁以及皮质骨和骨小梁椎骨中观察到最高吸收剂量，可将其视为死后尸检中内部90 Sr暴露生物标志物的合适候选者。在钙化犬组织中重建的剂量与在骨/牙齿尸检部位（或附近）固定的丙氨酸剂量计中EPR测量的剂量之间存在令人满意的相关性。实验提供了支持的观点，EPR回顾性剂量测定与钙化组织的内部曝光是独一无二的，在提供有用的信息所获得的剂量。(C)1999爱思唯尔科技有限公司。保留所有权利。
The results of the EPR dose reconstruction in calcified tissues of dog injected with Sr-90 are presented. It has been established that there is no essential difference in the values of doses absorbed in tooth tissues of teeth in symmetric positions in the mouth, whereas a significant difference occurs in the values of absorbed doses in teeth in nonsymmetric positions. In the case of 90Sr internal exposure the dose reconstruction in crown dentine plays an important role. It has been found that its quantity is close to the dose in diaphyseal cortical bone of the femur, dose at the endosteal bone surface and in femural fatty marrow. The fact that these values exceed doses absorbed in tooth enamel points out the predominant contribution of internal exposure. The highest absorbed doses have been observed in metaphyseal trabecular femur bones, tooth alveolar bone walls, and cortical and trabecular vertebra that can be considered as suitable candidates for biomarkers of internal 90Sr exposure for post-mortal autopsy. The satisfactory correlation has been found between the doses reconstructed in calcified dog tissues and the doses measured by EPR in alanine dosimeters fixed in (or nearby) the sites of autopsy of bones/teeth. The experiments provide support for the view that EPR retrospective dosimetry with calcified tissues for internal exposure is unique in providing useful information on the doses obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.