Biogenesis of lipoproteins in bacteria.
Biogenesis of lipoproteins in bacteria.
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DOI：
10.1007/978-3-642-71251-7_9
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发表时间：
1986
影响因子：
--
通讯作者：
H. C. Wu;M. Tokunaga
中科院分区：
文献类型：
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作者：
H. C. Wu;M. Tokunaga
大肠杆菌胞壁脂蛋白最早由BraunandRehn（1969）发现。随后，Inouye和他的同事发现了所谓的自由形式脂蛋白，它是大肠杆菌中主要的外膜蛋白之一。coli（Inouyeet al.1972）。胞壁脂蛋白的结构和生物合成的许多新特征之一是在其NH 2-末端存在脂氨基酸，N-酰基甘油酯-半胱氨酸。NH 2-末端甘油基半胱氨酸作为两个酯连接脂肪酸和一个酰胺连接脂肪酸的连接位点（HantkeandBraun 1973）。脂蛋白中的酯连接脂肪酸在组成上与散装磷脂中存在的酯连接脂肪酸相似，包括胞壁脂蛋白以及磷脂中存在的环丙烷脂肪酸。在脂蛋白中存在的酰胺连接脂肪酸中，65%为棕榈酸（HantkeandBraun 1973）。
The murein lipoprotein ofEscherichia coliwas first discovered byBraunandRehn(1969). Subsequently, the so-called free-form lipoprotein was discovered byInouyeand his coworkers as one of the major outer membrane proteins inE. coli(Inouyeet al. 1972). Among many novel features of the structure and biosynthesis of murein lipoprotein is the presence of a lipoamino acid at its NH2-terminus, N-acyl glyceride-cysteine. The NH2-terminal glycerylcysteine serves as the attachment site of two ester-linked fatty acids and one amide- linked fatty acid (HantkeandBraun1973). The ester-linked fatty acids in lipoproteins are similar in composition to those present in bulk phospholipids, including the presence of cyclopropane fatty acids in murein lipoprotein as well as in phospholipids. Of the amide-linked fatty acids present in lipoprotein, 65% were palmitic acid (HantkeandBraun1973).