Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types
Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types
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DOI：
10.1099/vir.0.055137-0
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发表时间：
2013-11-01
影响因子：
3.8
通讯作者：
Giri, Adriana A.
中科院分区：
文献类型：
--
作者：
Chouhy, Diego;Bolatti, Elisa M.;Giri, Adriana A.
超过170种人乳头瘤病毒（HPV）类型已被完全测序，策划并分为五个属：α乳头瘤病毒，β乳头瘤病毒，γ乳头瘤病毒，Mupapillomavirus和Nupapillomavirus。随着PCR方法的应用，数百种推定的新型HPV类型已被鉴定为粘膜和皮肤中的FOR扩增子。然而，目前还没有研究报告，目前已知的L1扩增子和它们的系统发育关系的系统搜索。这项调查显示，至少存在202种不同的推定HPV类型，有待全基因组表征：5种乳头瘤病毒，37种β乳头瘤病毒，159种γ乳头瘤病毒和1种穆乳头瘤病毒。α乳头瘤病毒属和β乳头瘤病毒属的所有潜在的病毒被分组在定义的物种，而59个推定的γ乳头瘤病毒类型被分离在21个未确定的推定物种。这些数据突出了需要在确定更多的分类单位的家庭乳头瘤病毒科，以阐明这些病毒的多样性，进化和医学意义的进展。
More than 170 human papillomavirus (HPV) types have been completely sequenced, curated and divided into five genera: Alphapapillomavirus, Betapapillomavirus, Gammapapillomavirus, Mupapillomavirus and Nupapillomavirus. With the application of PCR methods, hundreds of putative novel HPV types have been identified as FOR amplicons in mucosa and skin. However, at present there are no studies reporting a systematic search of the currently known L1 amplicons and their phylogenetic relationships. This survey revealed the existence of at least 202 different putative HPV types that are pending for full-genome characterization: five alphapapillomaviruses, 37 betapapillomaviruses, 159 gammapapillomaviruses and one mupapillomavirus. All potential viruses of the genera Alphapapillomavirus and Betapapillomavirus were grouped in the defined species, while 59 putative gammapapillomaviruses types were segregated in 21 unidentified putative species. These data highlight the need for progress in the identification of additional taxa of the family Papillomaviridae in order to elucidate the diversity, evolution and medical implications of these viruses.