Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.
Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.
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DOI：
10.1016/j.biomaterials.2016.04.018
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发表时间：
2016-08
期刊：
影响因子：
14
通讯作者：
Athanasiou KA
中科院分区：
文献类型：
--
作者：
Huang BJ;Hu JC;Athanasiou KA
软骨组织工程面临的最重要问题之一是无法将技术应用于临床。尽管有大量关于生物材料、信号和细胞范例的综述文章，但据报道，超过动物研究阶段的新药有90%在临床试验中失败。本综述的目的是让读者了解在人体中已显示出一定疗效的组织工程软骨产品的科学细节，以便在此基础上开发更新的技术。与现有的治疗方法，如微骨折或自体软骨细胞植入相比，组织工程产品在形成透明修复组织和填充整个缺损方面可能提供更一致的临床结果。从已发表的文献、公司网站和相关专利中收集到的用于形成这些产品的各种组织工程策略（例如，细胞扩增、支架材料、培养基配方、仿生刺激等）都进行了批判性讨论。作者指出，这些产品的许多细节仍然是专利性的，并非所有信息都公开，而且产品还在不断改进。然而，通过充分了解这些新兴技术的设计和生产过程，人们可以深入了解如何最好地使用它们以及如何设计下一代组织工程软骨产品。
One of the most important issues facing cartilage tissue engineering is the inability to move technologies into the clinic. Despite the multitude of review articles on the paradigm of biomaterials, signals, and cells, it is reported that 90% of new drugs that advance past animal studies fail clinical trials. The intent of this review is to provide readers with an understanding of the scientific details of tissue engineered cartilage products that have demonstrated a certain level of efficacy in humans, so that newer technologies may be developed upon this foundation. Compared to existing treatments, such as microfracture or autologous chondrocyte implantation, a tissue engineered product can potentially provide more consistent clinical results in forming hyaline repair tissue and in filling the entirety of the defect. The various tissue engineering strategies (e.g., cell expansion, scaffold material, media formulations, biomimetic stimuli, etc.) used in forming these products, as collected from published literature, company websites, and relevant patents, are critically discussed. The authors note that many details about these products remain proprietary, not all information is made public, and that advancements to the products are continuously made. Nevertheless, by fully understanding the design and production processes of these emerging technologies, one can gain tremendous insight into how to best use them and also how to design the next generation of tissue engineered cartilage products.