Tissue engineering of urinary bladder - current state of art and future perspectives.
Tissue engineering of urinary bladder - current state of art and future perspectives.
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DOI：
10.5173/ceju.2013.02.art23
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发表时间：
2013
影响因子：
1.2
通讯作者：
Drewa T
中科院分区：
文献类型：
--
作者：
Adamowicz J;Kowalczyk T;Drewa T
组织工程学和生物材料科学目前提供了取代尿道壁所需的技术。本文综述了组织工程学方法在尿路再生中的研究现状及存在的问题。Medline正在搜索膀胱组织工程、再生医学和干细胞。许多利用组织工程学方法开发天然膀胱壁替代品的研究正在进行中。干细胞与生物材料相结合开辟了新的治疗方法，甚至包括从头开始构建膀胱。然而，在将组织工程的进展引入临床应用之前，仍有许多问题需要解决。在组织工程技术被认为对患者有效和安全之前，未来还需要在大型动物模型上进行更多的研究和长期随访。
Tissue engineering and biomaterials science currently offer the technology needed to replace the urinary tract wall. This review addresses current achievements and barriers for the regeneration of the urinary blad- der based on tissue engineering methods. Medline was search for urinary bladder tissue engineering regenerative medicine and stem cells. Numerous studies to develop a substitute for the native urinary bladder wall us- ing the tissue engineering approach are ongoing. Stem cells combined with biomaterials open new treatment methods, including even de novo urinary bladder construction. However, there are still many issues before advances in tissue engineering can be introduced for clinical application. Before tissue engineering techniques could be recognize as effective and safe for patients, more research stud- ies performed on large animal models and with long follow–up are needed to carry on in the future.