Methodological issues in conducting treatment trials for psychological nonepileptic seizures.
Methodological issues in conducting treatment trials for psychological nonepileptic seizures.
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进行心理非癫痫发作治疗试验的方法学问题。
DOI：
10.1176/jnp.2007.19.4.391
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Keitner,GaborI
中科院分区：
文献类型：
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作者：
LaFranceJr,WCurt;Blum,AndrewS;Miller,IvanW;Ryan,ChristineE;Keitner,GaborI
一项在精神性非癫痫性发作（内斯）患者中进行的随机、安慰剂对照试验尚未完成。内斯的治疗出版物仅限于III类试验和IV类报告。关于内斯治疗试验的方法学研究很少。作者描述了这种试验的程序和局限性，以告知未来的内斯治疗试验，基于他们的前瞻性，开放标签的药理学，可行性试验。作者回顾了内斯患者的招募、入组、完成调查、依从性和随访。大多数入组的患者在试验期间完成了调查并服用了药物。筛选了12例患者，8例入组，6例完成试验。作者讨论了试验中结局和各种症状量表的使用。一个全面的神经精神初步评估和评估认知，情绪，行为和心理社会措施是重要的监测结果，内斯治疗随机对照试验。
A randomized, placebo-controlled trial has yet to be completed in patients with psychological nonepileptic seizures (NES). Treatment publications for NES are limited to class III trials and class IV reports. Little is written on the methodology of treatment trials in NES. The authors describe the procedures and limitations of such a trial to inform future NES treatment trials, based on their prospective, open-label pharmacological, feasibility trial. The authors review the recruitment, enrollment, completion of surveys, compliance, and follow-up of patients with NES. The majority of patients who enrolled, readily completed surveys and took the medication during the trial. Twelve patients were screened, eight enrolled, and six completed the trial. The authors discuss the use of outcomes and the various symptoms scales in the trial. A comprehensive neuropsychiatric initial assessment and assessing cognitive, emotional, behavioral, and psychosocial measures are important for monitoring the outcomes in NES treatment RCTs.