Ocular surface sealants and adhesives
Ocular surface sealants and adhesives
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DOI：
10.1016/s1542-0124(12)70041-1
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发表时间：
2006-07-01
期刊：
影响因子：
6.4
通讯作者：
Bhatia, Subir Singh
中科院分区：
文献类型：
--
作者：
Bhatia, Subir Singh
组织粘合剂，无论是合成的还是生物的，在眼科中的使用历史都很长。传统上，基于氰基丙烯酸酯的胶水是用于各种目的的最广泛使用的胶水。它们对于治疗角膜穿孔特别有用，并且显著改善了长期结果。最近，基于纤维蛋白的胶已经作为用于附着生物组织的缝合替代物和作为表面密封剂而获得了主要作用。文献支持以这种方式扩大使用纤维蛋白胶。其他新试剂，如聚乙二醇，尚未得到充分利用，但仍有希望，特别是作为表面保护剂。许多其他胶水正在开发中，并显示出作为眼表面密封剂和保护膜的前景。关于组织粘合剂的知识的进步导致更有效和高效的眼科护理。
Tissue adhesives, both synthetic and biologic, have a long history of use in ophthalmology. Cyanoacrylate-based glues have traditionally been the most widely used glues for various purposes. They have been especially useful for treating corneal perforations and have had significantly improved long-term outcomes. More recently, fibrin-based glues have gained a major role as a suture substitute for attaching biologic tissues and as surface sealants. The literature supports expanded use of fibrin glue in this fashion. Other new agents, such as polyethyelene glycols, have been underutilized and hold promise, especially as surface protectants. Numerous other glues are being developed and show promise as ocular surface sealants and protective membranes. Advances in knowledge about tissue adhesives are leading to more effective and efficient ophthalmic care.