Influence of macrophage infiltration of herniated lumbar disc tissue on outcome after lumbar disc surgery

Influence of macrophage infiltration of herniated lumbar disc tissue on outcome after lumbar disc surgery
复制标题

DOI：
10.1097/00007632-200004010-00017
复制
发表时间：
2000-04-01
期刊：
SPINE
影响因子：
3
通讯作者：
Brawanski, A
Brawanski, A
中科院分区：
医学2区
文献类型：
--
作者：
Woertgen, C;Rothoerl, RD;Brawanski, A

文献摘要

被引文献

相似文献

研究设计.对常规处理的腰椎间盘切除标本中炎性细胞的存在进行免疫组化检查，并将组织学结果与手术前后前瞻性收集的临床数据进行比较。评估腰椎间盘突出标本中炎症反应对腰椎间盘手术后结果的影响。对腰椎间盘突出组织的组织学和生物化学研究提出了炎症引起的坐骨神经痛的概念。在撰写本文时，还没有研究试图发现腰椎间盘手术后的结果如何受到组织学描述的炎症的影响。对79例腰椎间盘突出症手术患者的椎间盘标本进行了免疫组织学研究，以了解炎症反应的存在。其中，92%在手术后约7个月进行了随访。将组织学结果与随访结果进行比较。组织学证实的炎症与疼痛分级量表显示的结果之间存在统计学显著相关性。本研究的结果似乎支持异物对疝出材料反应的理论。这种反应可能导致炎症引起的坐骨神经痛。
Study Design. An immunohistochemical examination of the presence of inflammatory cells in routinely processed resection specimens of the lumbar disc, and a comparison of the histologic results with clinical data collected prospectively before and after surgery.Objectives. To assess the influence of inflammatory reactions in herniated lumbar disc specimens on the outcome after lumbar disc surgery.Summary of Background Data. Histologic and biochemical studies on herniated lumbar disc tissue led to the notion of inflammation-induced sciatic pain. At this writing, no investigations have sought to discover how outcome after lumbar disc surgery is influenced by histologically described inflammation.Methods. Disc specimens from 79 patients who underwent surgery for lumbar disc herniation were studied immunohistologically with regard to the presence of inflammatory reactions. Of these, 92% were followed up approximately 7 months after surgery. The histologic results were compared with the outcome at follow-up evaluation.Results. A statistically significant correlation was found between the histologically proven inflammation and the outcome, as shown by the pain grading scale.Conclusions. The results from this study seem to support the theory of a foreign body reaction to the herniated material. This reaction may result in inflammation-induced sciatic pain.