FACTORS INDUCING PERIODIC BREATHING IN HUMANS - A GENERAL-MODEL
FACTORS INDUCING PERIODIC BREATHING IN HUMANS - A GENERAL-MODEL
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DOI：
10.1152/jappl.1982.53.3.644
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发表时间：
1982-01-01
影响因子：
3.3
通讯作者：
SLUTSKY, AS
中科院分区：
文献类型：
--
作者：
KHOO, MCK;KRONAUER, RE;SLUTSKY, AS
开发了一个通用模型来解释由呼吸控制不稳定引起的各种周期性呼吸（PB）：在睡眠期间和急性暴露于高海拔，在睡眠中的婴儿和心血管或神经病变患者中。在几乎所有情况下，通气振荡主要是由外围控制器介导的。低氧、高碳酸血症、肺冲洗时间增加、肺化学感受器延迟延长和控制器敏感性降低了系统稳定性。大的肺CO2和O2储存量增强了稳定性，但不受身体组织储存量的影响。利用对肺耳延迟的测量，该模型预测PB的平均周期时间从0.0.1%减小。海平面30秒到14000英尺的20秒，与其他研究的数据非常吻合。相关参数的异速缩放也显示了模型预测与婴儿数据之间的密切一致。
A general model is developed to account for all kinds of periodic breathing (PB) resulting from instability in respiratory control: in normals during sleep and on acute exposure to high altitude, in sleeping infants and in patients with cardiovascular or neurologic lesions. In almost every case the ventilatory oscillation is mediated predominantly by the peripheral controller. System stability is decreased by hypoxia, hypercapnia, increased lung washout times, prolonged lung-chemoreceptor delays and with controller sensitivity. Stability is enhanced by large lung CO2 and O2 storage volumes but little affected by body tissue stores. Using measurements of lung-ear delays, the model predicts that the mean cycle time of PB decreases from .apprx. 30 s at sea level to 20 s at 14,000 ft, in excellent agreement with data from other studies. Allometric scaling of the relevant parameters also shows close agreement between model predictions and data obtained on infants.