Trans-myocardial omega-3 fatty acid gradient in coronary microvascular dysfunction.
Trans-myocardial omega-3 fatty acid gradient in coronary microvascular dysfunction.
复制标题
冠状动脉微血管功能障碍中的跨心肌 omega-3 脂肪酸梯度。
DOI：
10.1016/j.ahjo.2022.100213
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pepine,CarlJ
中科院分区：
文献类型：
--
作者：
Keeley,EllenC;Handberg,EileenM;NoelBaireyMerz,C;Pepine,CarlJ
心脏重塑是一个部分由欧米伽-3多不饱和脂肪酸二十碳五烯酸(EPA)的代谢产物18-羟基二十碳五烯酸(HEPE)介导的过程。结果冠状静脉血浆18-HEPE浓度为270.5 pg/mL[212.8~480.8]，主动脉血浆中18-HEPE浓度为430.5 pg/mL[299.5~655.8]，P=0.0039。冠状静脉血EPA浓度与主动脉18-HEPE浓度呈显著正相关(r=0.94，p=0.0002)，与主动脉18-HEPE浓度呈显著正相关(r=0.82，p=0.0058)。结论这一小型先导性研究结果支持18-HEPE在心外合成并在心肌床内利用的观点。
BackgroundCardiac remodeling is a process mediated, in part, by 18-hydroxyeicosapentaenoic acid (HEPE), a metabolite of the omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). We hypothesized that trans-myocardial levels of 18-HEPE could inform the pathophysiologic processes involved in heart failure with preserved ejection fraction (HFpEF).MethodsWe measured the concentration of 18-HEPE and EPA in trans-myocardial plasma samples from 10 subjects enrolled in The Women's Ischemia Syndrome Evaluation [WISE] Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-HFpEF project.ResultsConcentrations of 18-HEPE were significantly lower in coronary venous compared to the aortic plasma (270.5 pg/mL [212.8–480.8] vs. 430.5 pg/mL [299.5–655.8],p= 0.0039). There was a significant correlation between the concentrations of coronary venous EPA and aortic 18-HEPE (r= 0.94,p= 0.0002), and aortic EPA and aortic 18-HEPE (r= 0.82,p= 0.0058).ConclusionsResults of this small pilot study support the suggestion that 18-HEPE is synthesized outside the heart and utilized within the myocardial bed.