Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer
Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer
复制标题
DOI：
10.1007/s12149-010-0442-2
复制
发表时间：
2011-02-01
影响因子：
2.6
通讯作者：
Inoue, Tomio
中科院分区：
文献类型：
--
作者：
Kawano, Tsuyoshi;Ohtake, Eiji;Inoue, Tomio
目的 本研究的目的是确定与深吸气屏气 (DIBH) 和自由呼吸 (FB) PET/CT 与呼吸门控 (RG) PET 混合的最大标准化摄取值 (SUV(max)) 差异相关的因素，以供参考。 方法 对患有肺部病变的患者 (n = 95) 在一个机构进行超过 33 个月的评估。接受全身 PET/CT 后，获得 RG PET 和 FB PET/CT 扫描，然后进行 DIBH PET/CT 扫描。所有扫描均使用具有呼吸门控的列表模式动态收集方法进行记录。 RG PET 使用相位选通重建，无需衰减校正； FB PET 是根据带有衰减校正的 RG PET 正弦图数据集重建的。记录呼吸运动距离、呼吸周期速度和RG PET波形。记录 FB PET/CT 和 DIBH PET/CT 的 SUV(max)：FB 和 DIBH 扫描之间 SUV(max) 的百分比差异定义为 % BH 指数。 结果 下肺区域病变的 % BH 指数显着高于上肺区域。下肺区域的呼吸运动距离显着高于上肺区域。在 % BH 指数和呼吸运动距离之间观察到显着的关系。没有稳定到期末的波形往往显示出较高的 % BH 指数。在 % BH-index 和周期速度之间以及呼吸运动距离和周期速度之间观察到显着的负相关关系。结论 FB PET/CT SUV(max) 的下降是由于 (1) 肿瘤大小、(2) 下肺分布、(3) 缓慢呼吸周期速度下的长呼吸运动和 (4) 没有稳定呼气末的呼吸波形。
Objective The objective of this study was to define the factors that correlate with differences in maximum standardized uptake value (SUV(max)) in deep-inspiration breath-hold (DIBH) and free breathing (FB) PET/CT admixed with respiratory gating (RG) PET for reference.Methods Patients (n = 95) with pulmonary lesions were evaluated at one facility over 33 months. After undergoing whole-body PET/CT, a RG PET and FB PET/CT scans were obtained, followed by a DIBH PET/CT scan. All scans were recorded using a list-mode dynamic collection method with respiratory gating. The RG PET was reconstructed using phase gating without attenuation correction; the FB PET was reconstructed from the RG PET sinogram datasets with attenuation correction. Respiratory motion distance, breathing cycle speed, and waveform of RG PET were recorded. The SUV(max) of FB PET/CT and DIBH PET/CT were recorded: the percent difference in SUV(max) between the FB and DIBH scans was defined as the % BH-index.Results The % BH-index was significantly higher for lesions in the lower lung area than in the upper lung area. Respiratory motion distance was significantly higher in the lower lung area than in the upper lung area. A significant relationship was observed between the % BH-index and respiratory motion distance. Waveforms without steady end-expiration tended to show a high % BH-index. Significant inverse relationships were observed between % BH-index and cycle speed, and between respiratory motion distance and cycle speed.Conclusion Decrease in SUV(max) of FB PET/CT was due to (1) tumor size, (2) distribution of lower lung, (3) long respiratory movement at slow breathing cycle speeds, and (4) respiratory waveforms without steady end-expiration.