Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis
Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis
复制标题
米诺环素上调实验性自身免疫性脑脊髓炎中脑源性神经营养因子和神经生长因子的表达。
DOI：
10.1016/j.ejphar.2012.04.043
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发表时间：
2012-07-05
影响因子：
5
通讯作者：
Pi, Rongbiao
中科院分区：
文献类型：
--
作者：
Chen, Xiaohong;Ma, Lili;Pi, Rongbiao
既往研究表明，米诺环素可改善实验性自身免疫性脑脊髓炎的临床严重程度，并表现出多种抗炎和神经保护活性。然而，很少有研究评估其对实验性自身免疫性脑脊髓炎或多发性硬化症中神经营养蛋白表达的影响。本研究观察了米诺环素对实验性自身免疫性脑脊髓炎C57 BL/6小鼠血清、大脑皮质和腰髓中脑源性神经营养因子和神经生长因子的影响。米诺环素可上调实验性自身免疫性脑脊髓炎小鼠外周血（血清和脾细胞培养上清）和靶器官（大脑皮质和腰髓）脑源性神经营养因子和神经生长因子的表达。这些数据表明，上调神经营养因子在实验性自身免疫性脑脊髓炎可能是一种新的米诺环素的神经保护机制。(C)2012爱思唯尔有限公司版权所有。
Previous evidence demonstrated that minocycline could ameliorate clinical severity of experimental autoimmune encephalomyelitis and exhibit several anti-inflammatory and neuroprotective activities. However, few studies have been carried out to assess its effects on the expression of neurotrophins in experimental autoimmune encephalomyelitis or multiple sclerosis. Here we investigated the alteration of brain-derived neurotrophic factor and nerve growth factor in the sera, cerebral cortex, and lumbar spinal cord of experimental autoimmune encephalomyelitis C57 BL/6 mice in vivo as well as the splenocytes culture supernatants in vitro after minocycline administration. Our results demonstrated that minocycline could up-regulate the expression of brain-derived neurotrophic factor and nerve growth factor both in peripheral (sera and splenocytes culture supernatants) and target organs (cerebral cortex and lumber spinal cord) of mice with experimental autoimmune encephalomyelitis. These data suggest that up-regulation of neurotrophins in experimental autoimmune encephalomyelitis may be a novel neuroprotective mechanism of minocycline. (C) 2012 Elsevier B.V. All rights reserved.