ACE I/D gene polymorphism and aerobic endurance development in response to training in a non-elite female cohort.
ACE I/D gene polymorphism and aerobic endurance development in response to training in a non-elite female cohort.
复制标题
ACE I/D 基因多态性和有氧耐力发展对非精英女性群体训练的影响。
DOI：
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发表时间：
2006
影响因子：
1.7
通讯作者：
A. Berdeli
中科院分区：
文献类型：
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作者：
Sırrı Çam;M. Çolakoğlu;Ş. Çolakoğlu;C. Şekuri;A. Berdeli
目的
本研究的目的是调查 ACE 基因多态性与非精英女性群体中短期和中期有氧耐力表现改善之间的关联，以响应相同的训练方案。
方法
55 名土耳其非精英白人运动员接受训练，以提高对应于心率储备的 70% 和 90% 的跑步速度（分别为 V-HRR70 和 V-HRR90）30 分钟跑步速度表现（V-30 分钟），每周 3 次，持续 6 周。通过PCR分析研究ACE基因多态性。
结果
整个队列中，II (n=12)、ID (n=23) 和 DD (n=20) 的基因型分布分别为 21.8%、41.8%、36.4%。 ACE II基因型受试者在V-30min和V-HRR70方面的改善显着高于ACE DD组（P<0.05）。然而，在HRR90中，ACE DD基因型在跑步速度方面比其他基因型有更好的表现增强（P<0.05）。 V-HRR70 和 V-30 分钟的耐力改善呈线性趋势 II>ID>DD（分别为 P<0.05 和 P<0.01），而在 V-HRR90 中观察到线性趋势为 DD>ID>II（P<0.01）。
结论
ACE II 基因型可能与中等持续时间有氧耐力表现的更好改善有关，而 ACE DD 基因型似乎更有利于较短持续时间和较高强度耐力活动的表现增强。
AIM
The aim of this study was to investigate the association between ACE gene polymorphism and short- and medium-duration aerobic endurance performance improvements in response to the same training regimen in a non-elite female cohort.
METHODS
Fifty-five female non-elite Caucasian Turkish athletes trained to enhance running speeds corresponding to 70% and 90% of heart rate reserve (V-HRR70 and V-HRR90 respectively) 30 min running speed performance (V-30min) 3 times per week, for 6 weeks. ACE gene polymorphisms studied by PCR analysis.
RESULTS
The distribution of genotypes in the whole cohort was 21.8%, 41.8%, 36.4% for II (n=12), ID (n=23) and DD (n=20), respectively. Subjects with ACE II genotype had significantly higher improvements in V-30min and V-HRR70 than the ACE DD group (P<0.05). However, in HRR90 ACE DD genotype had a better performance enhancement in running speed than others (P<0.05). Endurance improvements in the V-HRR70 and in the V-30min showed a linear trend as II>ID>DD (P<0.05 and P<0.01, respectively) while a linear trend as DD>ID>II (P<0.01) observed in V-HRR90.
CONCLUSION
ACE II genotype may related with better improvements in medium duration aerobic endurance performance whilst ACE DD genotype seems to be more advantageous in performance enhancement in shorter duration and higher intensity endurance activities.
影响因子：
3.3
作者：
Hagberg, JM;Ferrell, RE;Moore, GE
通讯作者：
Moore, GE