KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.
KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.
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KIF5B 转运 BNIP-2 调节 p38 丝裂原激活蛋白激酶激活和成肌细胞分化
DOI：
10.1091/mbc.e14-03-0797
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发表时间：
2015-01-01
影响因子：
3.3
通讯作者：
Zhou YT
中科院分区：
文献类型：
--
作者：
Yi P;Chew LL;Zhang Z;Ren H;Wang F;Cong X;Zheng L;Luo Y;Ouyang H;Low BC;Zhou YT
CDO连接支架蛋白BNIP-2和JLP，在成肌细胞分化过程中激活p38MAPK。KIF5B是BNIP-2的一个新的相互作用伙伴，促进肌源性分化。依赖于KIF5B的BNIP-2转运是其促肌生作用的关键。
Cdo bridges scaffold proteins BNIP-2 and JLP to activate p38MAPK during myoblast differentiation. KIF5B is a novel interacting partner of BNIP-2 and promotes myogenic differentiation. KIF5B-dependent transport of BNIP-2 is essential for its promyogenic effects.