Group-wise construction of reduced models for understanding and characterization of pulmonary blood flows from medical images
Group-wise construction of reduced models for understanding and characterization of pulmonary blood flows from medical images
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DOI：
10.1016/j.media.2013.09.003
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发表时间：
2014-01-01
影响因子：
10.9
通讯作者：
Gerbeau, Jean-Frederic
中科院分区：
文献类型：
--
作者：
Guibert, Romain;McLeod, Kristin;Gerbeau, Jean-Frederic
患者特定几何形状的3D计算流体动力学（CFD）为临床成像提供了补充见解，以更好地了解心脏病以及治疗心脏病的副作用如何影响血流动力学以及受血流动力学影响。该信息可用于治疗计划，用于设计经受来自血流的应力和压力的人造装置。然而，这些模拟在临床背景下仍然相对昂贵。这项工作的目的是通过结合图像分析，计算流体动力学和模型降阶技术来降低患者特定模拟的复杂性。所提出的方法利用一个参考几何估计的平均人口，在一个有效的统计框架的基础上，目前的形状表示。在参考几何结构中执行的血流模拟的快照用于构建POD（本征正交分解）基础，然后可以将其映射到新患者上，以使用患者特定边界条件执行降阶血流模拟。将该方法应用于17例法洛四联症患者的数据集，以模拟正常（健康或合成瓣膜，几乎没有回流）和病理（瓣膜泄漏或缺失，回流）条件下通过肺动脉的血流，以更好地了解回流血液对流出道压力和速度的影响。通过在运动和不同程度的病理生理条件下进行患者模拟，基于参考溶液的减少（分别为静息和中等回流条件），进一步测试模型减少方法。(C)2013爱思唯尔有限公司版权所有。
3D computational fluid dynamics (CFD) in patient-specific geometries provides complementary insights to clinical imaging, to better understand how heart disease, and the side effects of treating heart disease, affect and are affected by hemodynamics. This information can be useful in treatment planning for designing artificial devices that are subject to stress and pressure from blood flow. Yet, these simulations remain relatively costly within a clinical context. The aim of this work is to reduce the complexity of patient-specific simulations by combining image analysis, computational fluid dynamics and model order reduction techniques. The proposed method makes use of a reference geometry estimated as an average of the population, within an efficient statistical framework based on the currents representation of shapes. Snapshots of blood flow simulations performed in the reference geometry are used to build a POD (Proper Orthogonal Decomposition) basis, which can then be mapped on new patients to perform reduced order blood flow simulations with patient specific boundary conditions. This approach is applied to a data-set of 17 tetralogy of Fallot patients to simulate blood flow through the pulmonary artery under normal (healthy or synthetic valves with almost no backflow) and pathological (leaky or absent valve with backflow) conditions to better understand the impact of regurgitated blood on pressure and velocity at the outflow tracts. The model reduction approach is further tested by performing patient simulations under exercise and varying degrees of pathophysiological conditions based on reduction of reference solutions (rest and medium backflow conditions respectively). (C) 2013 Elsevier B.V. All rights reserved.