Mentholated cigarette smoking and lung-cancer risk
Mentholated cigarette smoking and lung-cancer risk
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DOI：
10.1016/s1047-2797(98)00042-8
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发表时间：
1999-02-01
影响因子：
5.6
通讯作者：
London, SJ
中科院分区：
文献类型：
--
作者：
Carpenter, CL;Jarvik, ME;London, SJ
目的：与不含薄荷的香烟相比，含薄荷的香烟吸烟可能导致肺癌风险更大的增加。香烟的醇化会给香烟烟雾增加额外的致癌成分，并增加香烟烟雾在肺部的保留时间。只有两个流行病学研究已经进行了薄荷醇吸烟和肺癌，他们的结果是相互矛盾的，值得注意的是，非洲裔美国男性有更高的肺癌发病率比白人男性，尽管每天吸烟较少。由于消费的薄荷醇香烟是更频繁的非裔美国人，它是感兴趣的研究薄荷醇吸烟和肺癌风险之间的可能关联在此population.METHODS：我们研究了薄荷醇香烟冶炼和肺癌风险之间的关联吸烟者之间的肺癌病例对照研究中登记的478例肺癌的337例事件进行比较。信息吸烟史和其他已知的和潜在的肺癌的危险因素，包括饮食摄入量，获得了在人interviews.Results：调整后的比值比没有明显不同的薄荷香烟与专门的nonmentholated香烟吸烟者在整个研究组的吸烟者之间的冶炼厂。32包-年或以上含薄荷香烟与不含薄荷香烟的比值比（OR）为0.90（95%置信区间（CI）= 0.38-2.12），非裔美国人和1.06（95% CI = 0.47-2.36），两个种族组之间无差异结论：我们的研究结果表明，吸烟薄荷香烟的肺癌风险类似于吸烟非薄荷香烟的风险。我们的数据不支持非裔美国人肺癌风险增加是由于薄荷醇吸烟流行率增加的假设。(C)1999 Elsevier Science Inc. All rights reserved.
PURPOSE: Menthol smoking may lead to a greater increase in lung-cancer risk than smoking of nonmentholated cigarettes. Mentholation of cigarettes adds additional carcinogenic components to cigarette smoke and increases retention times for cigarette smoke in the lungs. Only two epidemiologic studies have been conducted on menthol smoking and lung cancer, and their results are conflicting, Of note, African American males have much higher rates of lung cancer than Caucasian males despite smoking fewer cigarettes per day. Because the consumption of menthol cigarettes is much more frequent among African Americans, it is of interest to examine the possible association between menthol smoking and lung-cancer risk in this population.METHODS: We examined the association between menthol cigarette smelting and lung-cancer risk among smokers by comparing 337 incident cases of lung cancer with 478 population controls enrolled in a case-control study of lung cancer. Information on smoking history and other known and potential risk factors for lung cancer, including dietary intake, was obtained by in-person interviews.RESULTS: The adjusted odds ratios did not differ appreciably between smelters of mentholated cigarettes versus exclusive nonmentholated cigarette smokers in the overall study group of smokers. The odds ratio (OR) for 32 pack-years or more of mentholated vs. nonmentholated cigarettes was 0.90 (95% confidence interval (CI) = 0.38-2.12) in African Americans and 1.06 (95% CI = 0.47-2.36) in Caucasians, and did not differ for either ethnic group (p = 0.98).CONCLUSIONS: Our results suggest that the lung-cancer risk from smoking mentholated cigarettes resembles the risk from smoking non-mentholated cigarettes. Our data do not support the hypothesis that the increased risk of lung cancer among African Americans is due to the increased prevalence of menthol smoking. (C) 1999 Elsevier Science Inc. All rights reserved.