Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies.
Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies.
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DOI：
10.1016/j.wjorl.2016.03.002
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Abuzeid WM
中科院分区：
文献类型：
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作者：
Fastenberg JH;Hsueh WD;Mustafa A;Akbar NA;Abuzeid WM
越来越多的证据表明，生物膜对慢性感染（包括慢性鼻窦炎（CRS））的病理生理学至关重要。直到最近，我们对生物膜的了解还是有限的。生物膜鉴定和分子生物学方法的最新进展为生物膜在CRS中的作用提供了新的见解。有了这些见解，研究人员已经开始研究新的治疗策略，可能会破坏或消除CRS中的生物膜。本文旨在探讨CRS中生物膜的证据，讨论潜在的抗生物膜治疗策略，并提出未来的研究方向。现有证据强烈支持生物膜在CRS发病机制中的作用。已经研究了用于CRS的几种抗生物膜疗法，并且这些疗法处于不同的开发阶段。通常，这些策略：1）中和生物膜微生物; 2）分散现有的生物膜;或3）破坏群体感应。几个最有前途的抗生物膜的治疗策略进行了审查。更好地了解生物膜功能及其对CRS疾病过程的贡献将是开发新治疗方法的关键，这些治疗方法可能会增加并可能重新定义CRS治疗模式。未来的研究潜力巨大。
There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have begun to investigate novel therapeutic strategies that may disrupt or eradicate biofilms in CRS. This review seeks to explore the evidence implicating biofilms in CRS, discuss potential anti-biofilm therapeutic strategies, and suggest future directions for research. The existing evidence strongly supports the role of biofilms in the pathogenesis of CRS. Several anti-biofilm therapies have been investigated for use in CRS and these are at variable stages of development. Generally, these strategies: 1) neutralize biofilm microbes; 2) disperse existing biofilms; or 3) disrupt quorum sensing. Several of the most promising anti-biofilm therapeutic strategies are reviewed. A better understanding of biofilm function and their contribution to the CRS disease process will be pivotal to the development of novel treatments that may augment and, potentially, redefine the CRS treatment paradigm. There is tremendous potential for future research.