Drosophotoxicology: An Emerging Research Area for Assessing Nanoparticles Interaction with Living Organisms.
Drosophotoxicology: An Emerging Research Area for Assessing Nanoparticles Interaction with Living Organisms.
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DOI：
10.3390/ijms17020036
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发表时间：
2016-02-14
影响因子：
5.6
通讯作者：
Ecovoiu AA
中科院分区：
文献类型：
--
作者：
Chifiriuc MC;Ratiu AC;Popa M;Ecovoiu AA
纳米技术的迅速发展使得人们可以制造各种不同的纳米材料，这引发了许多关于其安全性以及对人类健康和环境的潜在风险的问题。目前大多数纳米毒理学研究都没有标准化，阻碍了所获得结果的任何比较或再现性。果蝇毒理学包含了大量的方法论方法，这些方法论方法将黑腹果蝇作为毒理学研究中的一种选择生物。黑腹果蝇模型具有几个重要的优势，例如相对简单的基因组结构、较短的寿命、较低的维护成本、从伦理和技术角度来看与脊椎动物模型相比实验操作的准备程度、与高等生物的相关基因同源性以及易于获得突变表型。分子途径以及多种行为和发育参数可以使用该模型在低、中或高通量类型的测定中进行评估，从而对不同纳米材料的毒性水平进行系统分类。本文的目的是审查目前的研究应用果蝇模型在体内评估纳米颗粒的毒性，并揭示了巨大的潜力，该模型系统提供的结果，可以使一个适当的选择不同的纳米结构，为一定的生物医学应用。
The rapid development of nanotechnology allowed the fabrication of a wide range of different nanomaterials, raising many questions about their safety and potential risks for the human health and environment. Most of the current nanotoxicology research is not standardized, hampering any comparison or reproducibility of the obtained results. Drosophotoxicology encompasses the plethora of methodological approaches addressing the use of Drosophila melanogaster as a choice organism in toxicology studies. Drosophila melanogaster model offers several important advantages, such as a relatively simple genome structure, short lifespan, low maintenance cost, readiness of experimental manipulation comparative to vertebrate models from both ethical and technical points of view, relevant gene homology with higher organisms, and ease of obtaining mutant phenotypes. The molecular pathways, as well as multiple behavioral and developmental parameters, can be evaluated using this model in lower, medium or high throughput type assays, allowing a systematic classification of the toxicity levels of different nanomaterials. The purpose of this paper is to review the current research on the applications of Drosophila melanogaster model for the in vivo assessment of nanoparticles toxicity and to reveal the huge potential of this model system to provide results that could enable a proper selection of different nanostructures for a certain biomedical application.