Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
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DOI：
10.1016/s0925-4927(02)00004-5
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发表时间：
2002-06-15
影响因子：
2.3
通讯作者：
Miller, EN
中科院分区：
文献类型：
--
作者：
Chang, L;Ernst, T;Miller, EN
本研究的目的是确定可能的持续性异常，局部脑血流量（相对脑血流量）和认知功能的戒毒甲基苯丙胺（METH）用户。20 METH依赖的主题（禁欲8 - 2个月）和20个年龄和性别匹配的对照进行了评价与灌注磁共振成像（pMRI）和神经心理测试。METH使用者双侧壳核/岛叶皮质（右侧：-12%;左侧：-10%）和右侧顶叶脑区（-11%）的相对rCBF降低，但双侧左侧颞顶白色物质（+ 13%）、左侧枕叶脑区（+ 10%）和右侧后顶叶区（+24%）的相对rCBF增加。在右枕叶皮质和中线脑区观察到METH和性别之间的相互作用效应;女性METH使用者显示相对rCBF增加（两个区域均为+15%），而男性METH使用者相对rCBF下降（分别为-10%和-18%）。METH使用者在标准神经心理学测试中的表现在正常范围内;然而，他们在加州计算机化评估包（CalCAP）的几项任务中表现较慢，特别是需要工作记忆的任务。这些发现表明，甲基苯丙胺滥用与大脑中持续的生理变化有关，这些变化伴随着认知功能计算机测量的反应时间变慢。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
This study aims to determine possible persistent abnormalities in regional cerebral blood flow (relative rCBF) and cognitive function in abstinent methamphetamine (METH) users. Twenty METH-dependent subjects (abstinent for 8 2 months) and 20 age- and gender-matched controls were evaluated with perfusion magnetic resonance imaging (pMRI) and neuropsychological tests. METH users showed decreased relative rCBF bilaterally in putamen/insular cortices (right: - 12%; left: - 10%) and the right lateral parietal brain region ( - 11%), but increased relative rCBF bilaterally in the left temporoparietal white matter ( + 13%), the left occipital brain region: ( + 10%) and the right posterior parietal region (+24%). Interaction effects were observed between METH and gender in the right occipital cortex and a midline brain region; female METH users showed increased relative rCBF (+ 15% both regions) whereas the male METH users had decreased relative rCBF (- 10% and - 18%, respectively). METH users performed within normal ranges on standard neuropsychological tests; however, they were slower on several tasks on the California Computerized Assessment Package (CalCAP), especially tasks that required working memory. These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.