Comparison of aorta and pulmonary artery: I. Early cholesterol accumulation and relative susceptibility to atheromatous lesions.
Comparison of aorta and pulmonary artery: I. Early cholesterol accumulation and relative susceptibility to atheromatous lesions.
复制标题
主动脉和肺动脉的比较： 一、早期胆固醇积累和动脉粥样硬化病变的相对易感性。
DOI：
10.1161/01.res.81.3.338
复制
发表时间：
1997
影响因子：
20.1
通讯作者：
Schwenke,DC
中科院分区：
文献类型：
--
作者：
Schwenke,DC
在兔子中，肺动脉和主动脉容易发生动脉粥样硬化。然而，与主动脉弓相比，肺动脉对动脉粥样硬化的易感性以及动脉粥样硬化形成早期阶段胆固醇积聚与这些动脉区域动脉粥样硬化病变发展之间的关系仍有待澄清。在正常家兔和喂食0.5%胆固醇饲料8、12、16天和17周的家兔中测量肺动脉和主动脉的胆固醇浓度。在正常家兔中，动脉胆固醇浓度的顺序为肺动脉>主动脉弓>胸降主动脉，肺动脉总胆固醇和非酯化胆固醇浓度分别比胸降主动脉高17%和25%（P <0.05）。等级顺序保持不变，在16天的胆固醇喂养，但动脉区域之间的差异被夸大。在给家兔喂食胆固醇16天后，肺动脉的总胆固醇和酯化胆固醇浓度分别比胸降主动脉高57%和920%（均P <0.01），而主动脉区域之间的差异要小得多。与此相反，在喂饲胆固醇17周后，肺动脉和主动脉弓中总胆固醇、酯化胆固醇和非酯化胆固醇的浓度相似，但主动脉弓中这些形式的胆固醇分别比胸降主动脉增加100%、130%和53%（均P <0.03）。在胆固醇喂养的前16天，肺动脉的胆固醇浓度与主动脉区域的胆固醇浓度呈正相关，但对于喂养胆固醇17周的兔子，这种相关性要么是负相关的，要么是不存在的。这些结果表明，在动脉粥样硬化形成的不同阶段，肺动脉和主动脉中胆固醇积累的相对速率不同，并表明在动脉粥样硬化形成期间，在这些动脉区域中，将胆固醇输送到动脉和从动脉中去除胆固醇的过程之间的平衡可能以不同的方式改变。
In rabbits, the pulmonary artery and the aorta are susceptible to atherosclerosis. However, susceptibility of the pulmonary artery, compared with the aortic arch, to atherosclerosis and the relationship between the accumulation of cholesterol during the early stages of atherogenesis and the development of atheromatous lesions for these arterial regions remain to be clarified. Cholesterol concentrations for the pulmonary artery and aorta were measured in normal rabbits and in rabbits fed a 0.5% cholesterol diet for 8, 12, and 16 days and 17 weeks. In normal rabbits, the rank order of arterial cholesterol concentrations was pulmonary artery>aortic arch>descending thoracic aorta, with concentrations of total and nonesterified cholesterol 17% and 25% (bothP<.05) greater, respectively, for the pulmonary artery than for the descending thoracic aorta. Rank order remained the same during 16 days of cholesterol feeding, but differences between arterial regions were exaggerated. After rabbits were fed cholesterol for 16 days, total and esterified cholesterol concentrations were 57% and 920% (bothP<.01) greater, respectively, for the pulmonary artery than for the descending thoracic aorta, with much smaller differences between the aortic regions. In contrast, after rabbits were fed cholesterol for 17 weeks, concentrations of total, esterified, and nonesterified cholesterol were similar for the pulmonary artery and aortic arch, but these forms of cholesterol were increased 100%, 130%, and 53% (allP<.03), respectively, for the aortic arch compared with the descending thoracic aorta. Cholesterol concentrations for the pulmonary artery were positively associated with those for the aortic regions during the first 16 days of cholesterol feeding, but for rabbits fed cholesterol for 17 weeks the associations were either negative or absent. These results indicate that relative rates of cholesterol accumulation in the pulmonary artery and aorta differ at different stages of atherogenesis and suggest that the balance between processes that deliver cholesterol to, and remove cholesterol from, the artery may change in different ways in these arterial regions during atherogenesis.