A SEQUENCE PATTERN COMMON TO T-CELL EPITOPES
A SEQUENCE PATTERN COMMON TO T-CELL EPITOPES
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DOI：
10.1002/j.1460-2075.1988.tb02787.x
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发表时间：
1988-01-01
期刊：
影响因子：
11.4
通讯作者：
TAYLOR, WR
中科院分区：
文献类型：
--
作者：
ROTHBARD, JB;TAYLOR, WR
对已知的细胞毒性和辅助性T细胞表位的分析揭示了它们的一级序列内的相似性。这些相似的基序，已知的决定簇的特征，已被纳入预测模板，已被成功地用于定义八个辅助和三个细胞毒性表位在四种不同的蛋白质。当限定的表位被限制性元件分离时，等位基因特异性子模式以一般模式为中心出现。相似性的存在表明肽抗原与I类和II类的结合本质上是相似的。此外，这些基序可用于准确预测蛋白质内能够被单个MHC I类和II类分子识别的区域。
An analysis of the known cytotoxic and helper T cell epitopes has revealed similarity within their primary sequences. These similar motifs, characteristic of the known determinants, have been incorporated into predictive templates that have been used successfully to define eight helper and three cytotoxic epitopes in four different proteins. When the defined epitopes are segregated by restriction element, allele specific subpatterns emerge centering around the general pattern. The presence of similarities argues that the binding of peptide antigens to class I and class II is similar in nature. In addition, these motifs can be used to predict accurately areas within proteins capable of being recognized by individual MHC class I and class II molecules.