The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population
The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population
复制标题
DOI：
10.1097/00001648-199703000-00005
复制
发表时间：
1997-03-01
期刊：
影响因子：
5.4
通讯作者：
Stieber, J
中科院分区：
文献类型：
--
作者：
Keil, U;Chambless, LE;Stieber, J
流行病学研究表明，从啤酒、葡萄酒或烈性酒中少量或适度饮酒与全因死亡率的降低有关，这主要是由于降低了冠心病(CHD)的风险。为了找出这种小剂量到中等剂量酒精的保护作用是否可以在德国得到证实，在德国，人们消费的大部分酒精都是以啤酒的形式摄入的，我们研究了酒精与先天性心脏病和总死亡率的关系。我们从1984年到1992年对奥格斯堡地区1,071名男性和1,013名女性进行了前瞻性一致性研究，基线年龄为45岁-。87%的男性和56%的女性报告在基线水平上饮酒。在饮酒者中，男性平均每天摄入42克酒精，其中33克来自啤酒。饮酒的女性平均每天的酒精摄入量为16克，其中约一半来自啤酒，另一半来自葡萄酒。在8年的随访中，男性发生了96例死亡(全因)和62例突发冠心病事件(非致命性和致命性)，女性发生了45例死亡(所有原因)。调整了一些潜在的混杂因素，在男性中，饮酒者与不饮酒者相比，调整后的CHD事件危险比(HRR)为0.51[95%可信区间(CI)=0.27-0.95]；这种保护作用始于每天0.1-19.9克的酒精类别，随着饮酒量的增加变化不大。在男性中，饮酒者与不饮酒者调整后的总死亡率HRR为0.59(95%CI=0.36-0.97)。不同饮酒组与不饮酒者的总死亡率HRR呈U型曲线，20~39.9g/d饮酒组的HRR最低为0.46(95%CI=0.20~0.80)，大于等于80g/d饮酒组的HRR最低为1.04(95%CI=0.54~2.00)。在女性中，每天饮酒19.9克的女性与不饮酒的女性相比，总死亡率HRR为0.46(95%CI=0.22-0.96)。
Epidemiologic studies indicate that light to moderate alcohol consumption from beer, wine, or spirits is associated with a reduction in all-cause mortality, owing primarily to a reduced risk of coronary heart disease (CHD). To find out whether this protective effect of small to moderate amounts of alcohol could be confirmed in Germany, where much of the alcohol consumed is taken in the form of beer, we studied the relation between alcohol and CHD and total mortality in a population of southern Germany. We conducted a prospective cohere study from 1984 to 1992 among 1,071 men and 1,013 women, age 45-64 years at baseline, from the Augsburg region. Eighty-seven per cent of men and 56% of women reported drinking alcohol at baseline. Among drinkers, men had an average alcohol intake of 42 gm per day, of which 33 gm per day came from beer. Women who drank had an average alcohol intake of 16 gm per day and derived about half of it from beer and the other half from wine. During the 8 years of follow up, 96 deaths (all causes) and 62 incident CHD events (nonfatal and fatal) occurred in men, and 45 deaths (all causes) occurred in women. Adjusting for a number of potential confounders, in men the adjusted hazard rate ratio (HRR) of CHD events for drinkers as compared with nondrinkers was 0.51 [95% confidence interval (CI) = 0.27-0.95]; this protective effect starts with the 0.1-19.9 gm per day alcohol category and does not change much with higher intake. In men, the adjusted total mortality HRR for drinkers as compared with nondrinkers was 0.59 (95% CI = 0.36-0.97). The total mortality HRRs for the different alcohol groups compared with nondrinkers show a U-shaped curve, with the lowest HRR of 0.46 (95% Cl = 0.20-0.80) for the 20-39.9 gm per day alcohol group and an HRR of 1.04 (95% CI = 0.54-2.00) for the greater than or equal to 80 gm per day alcohol group. In women, the total mortality HRR for those drinking up to 19.9 gm per day as compared with nondrinkers was 0.46 (95% CI = 0.22-0.96).