The renin-angiotensin system and thirst: a reevaluation. II. Drinking elicited in rats by caval ligation or isoproterenol.
The renin-angiotensin system and thirst: a reevaluation. II. Drinking elicited in rats by caval ligation or isoproterenol.
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肾素-血管紧张素系统和口渴：重新评估。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
E. Stricker
中科院分区：
文献类型：
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作者：
E. Stricker
结扎下腔静脉和给予异丙肾上腺素已被证明可以刺激大鼠的肾素分泌和增加饮水量。然而，目前的实验表明，这些治疗产生的血浆肾素活性不占所观察到的饮酒行为的20%以上。动脉血压的直接测量进一步表明，肾切除大鼠在腔静脉结扎或异丙肾上腺素治疗后进入肿胀性休克。通过全身注射高渗NaCl溶液、肾素或垂体后叶素，或通过颅内注射血管紧张素，在这些水肿动物中引起饮水，但在每种情况下也观察到血压迅速升高。因此，肾切除术似乎通过破坏这些动物的一般行为能力而不是通过消除特定的致渴刺激来减少饮水量。这些和其他结果表明，饮水引起的大鼠腔静脉结扎或异丙肾上腺素是不介导的肾素-血管紧张素系统。
Ligation of the inferior vena cava and administration of isoproterenol have been shown to stimulate renin secretion and to augment water intake in rats. However, the present experiments suggested that the plasma renin activities produced by these treatments do not account for more than 20% of the observed drinking behavior. Direct measurements of arterial blood pressure further indicated that nephrectomized rats go into hypotensive shock after caval ligation or isoproterenol treatment. Drinking was elicited in these hypotensive animals by systemic injection of hypertonic NaCl solution, renin, or Pitressin, or by intracranial injection of angiotensin, but in each case a rapid increase in blood pressure also was observed. Thus, it appears that nephrectomy reduces water intake in these animals by undermining their general capacity to behave rather than by removing a specific dipsogenic stimulus. These and other results suggested that drinking elicited in rats by caval ligation or isoproterenol is not mediated by the renin-angiotensin system.