DIETARY-PROTEIN INDUCED COLITIS IN BREAST-FED INFANTS
DIETARY-PROTEIN INDUCED COLITIS IN BREAST-FED INFANTS
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DOI：
10.1016/s0022-3476(82)80008-5
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发表时间：
1982-01-01
影响因子：
5.1
通讯作者：
HAMILTON, SR
中科院分区：
文献类型：
--
作者：
LAKE, AM;WHITINGTON, PF;HAMILTON, SR
据报道，6名婴儿在出生后第1个月纯母乳喂养时发生炎症性直肠炎。所有婴儿均足月出生，围产期正常。除带血腹泻外，无生长衰竭或体质症状。未发现毒性、细菌性、病毒性或寄生性病因。直肠炎症提示粪便白细胞的存在，并通过乙状结肠镜观察局灶性溃疡，水肿和脆性增加得到证实。直肠活检显示广泛的急性和慢性炎症改变。所有的婴儿在临床上都对以水解酪蛋白或大豆蛋白为基础的配方奶粉开始喂养有反应。随后，6名婴儿中有5名恢复母乳喂养：所有婴儿均立即出现症状复发。从母亲的饮食中去除牛奶蛋白导致2名婴儿对母乳喂养产生耐受性，但其他3名婴儿没有变化。膳食蛋白引起的小肠结肠炎，以前在配方奶喂养的婴儿中有报道，可能偶尔也发生在纯母乳喂养的婴儿中。
Six infants are reported who developed an inflammatory proctocolitis in the 1st mo. of life while being breast-fed exclusively. All were born at term and had normal perinatal courses. None had growth failure or constitutional symptoms other than bloody diarrhea. No toxic, bacterial, viral or parasitic cause was established. Rectal inflammation was suggested by the presence of fecal leukocytes and was confirmed by sigmoidoscopic observation of focal ulcerations, edema and increased friability. Rectal biopsies demonstrated a wide spectrum of acute and chronic inflammatory changes. All infants responded clinically to initiation of feeding with either a hydrolyzed casein or a soy protein-based formula. Breast-feeding was subsequently resumed in 5 of the 6 infants: all experienced immediate recurrence of symptoms. Elimination of cow''s milk protein from the maternal diet led to tolerance of breast-feeding in 2 infants, but there was no change in the other 3. Dietary protein-induced enterocolitis, previously reported in formula-fed infants, probably occurs occasionally in the exclusively breast-fed infant as well.