Relation of increase in adiposity mass from childhood to increase in left ventricular to young adulthood
Relation of increase in adiposity mass from childhood to increase in left ventricular to young adulthood
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DOI：
10.1016/j.amjcard.2006.02.044
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发表时间：
2006-08-01
影响因子：
2.8
通讯作者：
Steinberger, Julia
中科院分区：
文献类型：
--
作者：
Sivanandam, Shanthi;Sinaiko, Alan R.;Steinberger, Julia
这项研究评估了肥胖对从儿童期到成年的左心室（LV）质量进展的影响以及LV质量与成年年轻人的胰岛素抵抗的关系。在平均13岁的纵向研究中招募了一百三十二个健康的儿童，并在27岁时重新评估，此时还研究了胰岛素抵抗研究。对LV质量进行超声心动图评估，并索引高度为2.7。 13年时的体重指数（BMI）与BMI高度相关，在27年时，LV质量指数在13和27年时也是如此。 LV质量指数和BMI在13年（r = 0.38，p <0.0001）的横截面相关性大大增强了27年（r = 0.55，p <0.0001）。 BMI的增加> = 5.5 kg/m（2）从13年到27年，LV质量指数明显高于BMI变化<5.5 kg/m（2），并且这种关系明显更大。在基线时瘦而沉重的孩子中相似。在成年期，LV质量指数与瘦质量的关系弱于LV质量指数与脂肪质量的关系。 LV质量与胰岛素抵抗的关联取决于肥胖。总之，肥胖和LV质量在童年时期是相关的，这种关联跟踪并在成年后变得更强壮。此外，从儿童期到年轻成年的LV质量增加与BMI的增加有关，与BMI的增加有关，与BMI无关，这表明LV质量的过度增加可能会受到青春期体内脂肪增益的限制。 （c）2006 Elsevier Inc.保留所有权利。
This study evaluated the influence of adiposity on the progression of left ventricular (LV) mass from childhood to adulthood and the relation of LV mass to insulin resistance in young adulthood. One hundred thirty-two healthy children recruited into a longitudinal study at a mean age of 13 years and reevaluated at 27 years, at which time insulin resistance studies were also performed, were studied. Echocardiographic assessment of LV mass was made and indexed for height 2.7. Body mass index (BMI) at 13 years was highly correlated with BMI at 27 years, as was LV mass index at 13 and 27 years. The cross-sectional correlation of LV mass index and BMI at 13 years (r = 0.38, p < 0.0001) had strengthened considerably by 27 years (r = 0.55, p < 0.0001). A BMI increase >= 5.5 kg/m(2) from 13 to 27 years was associated with a significantly greater increase in the LV mass index (p < 0.0001) than a BMI change < 5.5 kg/m(2), and this relation was similar in children who were thin and heavy at baseline. In young adulthood, the relation of LV mass index to lean mass was weaker than that of LV mass index to fat mass. The association of LV mass with insulin resistance was dependent on adiposity. In conclusion, adiposity and LV mass are related in childhood, and this association tracks and becomes stronger in young adulthood. Moreover, the increase in LV mass from childhood to young adulthood is related to the degree of increase in BMI, independent of BMI at 13 years, suggesting that an excessive increase in LV mass could be limited by controlling gain in body fat during adolescence. (c) 2006 Elsevier Inc. All rights reserved.