The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6‐hydroxydopamine microinjection in the substantia nigra
The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6‐hydroxydopamine microinjection in the substantia nigra
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DOI：
10.1111/apha.12229
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发表时间：
2014-06
影响因子：
6.3
通讯作者：
L.‐F. Zheng;J. Song;Ruifang Fan;C-L Chen;Q-Z Ren;X-L Zhang;X. Feng;Y. Zhang;L.‐S. Li
中科院分区：
文献类型：
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作者：
L.‐F. Zheng;J. Song;Ruifang Fan;C-L Chen;Q-Z Ren;X-L Zhang;X. Feng;Y. Zhang;L.‐S. Li
胃轻瘫是帕金森病（PD）常见的非运动系统症状。然而，胃运动异常的机制尚不清楚。我们之前报道过 6-羟基多巴胺 (6-OHDA) 大鼠的胃动力受损，这些大鼠在黑质 (SN) 双侧显微注射 6-OHDA 进行治疗。我们推测胃组织中多巴胺系统的增强和乙酰胆碱 (Ach) 的减少可能导致 PD 中观察到的胃排空延迟。
Gastroparesis is a common non‐motor system symptom of Parkinson's disease (PD). However, the mechanism responsible for the gastric motor abnormality is not clear. We previously reported on the impaired gastric motility in 6‐hydroxydopamine (6‐OHDA) rats, which were treated with a bilateral microinjection of 6‐OHDA in the substantia nigra (SN). We hypothesize that the enhanced dopamine system and reduced acetylcholine (Ach) in gastric tissues might contribute to the delayed gastric emptying observed in PD.