INDIVIDUAL PEROXISOMAL BETA-OXIDATION ENZYMES
INDIVIDUAL PEROXISOMAL BETA-OXIDATION ENZYMES
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DOI：
10.1111/j.1749-6632.1982.tb21403.x
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发表时间：
1982-01-01
影响因子：
5.2
通讯作者：
HASHIMOTO, T
中科院分区：
文献类型：
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作者：
HASHIMOTO, T
以三酰甘油形式储存的脂肪酸是动物的主要燃料储备，很容易被大多数组织使用，但也有一些特殊的例外，例如神经细胞和红细胞。组织中的脂肪酸降解主要通过氧化进行，涉及连续氧化去除长链脂肪酸羧基端的乙酰基。一直以来，P-氧化被认为只发生在动物组织的线粒体基质中，直到1976年Lazarow和de Duve报道了大鼠肝脏过氧化物酶体中存在0-氧化系统。“过氧化物酶体、&氧化的发现对于脂质研究领域的进展具有重要意义。”对该系统的生理意义进行了广泛的研究。对过氧化物酶体氧化系统中酶特性的研究对于表征这一新系统的性质和生理作用至关重要。在本文中，我们描述了大鼠肝脏过氧化物酶体单个酶的分子和催化特性。
Fatty acids, stored as triacylglycerols, are the main fuel reserves of animals and are readily used by most tissues, with a few specialized exceptions such as nerve cells and erythrocytes. Fatty acid degradation in tissues proceeds mainly through@-oxidation, which involves the successive oxidation removal of acetyl groups from the carboxyl end of long-chain fatty acids. P-Oxidation had been believed to occur only in the mitochondrial matrix in animal tissues until Lazarow and de Duve reported the presence of a 0-oxidation system in rat liver peroxisomes in 1976.'The discovery of peroxisomal, &oxidation is of great importance for the progress of the field of lipid research. Extensive studies on the physiological significance of the system have been undertaken. Studies on the properties of the enzymes in the peroxisomal@-oxidation system are essential to characterize the nature and physiological role of this novel system. In this paper we describe the molecular and catalytic properties of individual enzymes of rat liver peroxisomes.