Structures and connections of enkephalin- and γ-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study
Structures and connections of enkephalin- and γ-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study
复制标题
孤束核味觉区脑啡肽和γ-氨基丁酸免疫反应谱的结构和联系：光和电子显微镜研究
DOI：
10.1007/s10072-010-0387-1
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发表时间：
2011
影响因子：
3.3
通讯作者：
Xiao
中科院分区：
文献类型：
--
作者：
Wei Huang;Juxiang Chen;Yi;Yi;Xiao
GABA和脑啡肽（ENK）是孤束核（rNTS）吻侧部调节味觉信息的主要抑制性递质。虽然存在的GABA和ENK-免疫反应（IR）配置文件中的rNTS已被证明，有没有形态学数据揭示它们之间的联系。本研究采用免疫荧光和电镜方法，研究了它们在大鼠rNTS中的相互关系。结果表明：（2）ENK阳性终末主要与GABA阳性和免疫阴性胞体及树突形成对称性突触，（3）ENK/GABA阳性轴突终末共存，ENK和GABA阳性终末会聚于一个免疫阴性索马或树突上。这些结果提示ENK对rNTS内的味觉神经元有直接抑制或间接兴奋（通过阻断GABA能神经元的抑制）作用。
GABA and enkephalin (ENK) are principle inhibitory transmitters in the rostral portion of the nucleus tractus solitarius (rNTS) for regulating the gustatory information. Although the existence of GABA- and ENK-immunoreactive (ir) profiles in the rNTS has been demonstrated, there are no morphological data revealing the connections between them. In the present study, using immunofluorescent and electron microscopic methods, we examined their relationship in the rNTS of rat. Results showed the following: (1) dense ENK-ir fibers and terminals and GABA-ir cell bodies, fibers, and terminals were observed in the rNTS; (2) ENK-ir terminals mainly make symmetric synapses with GABA-ir and immunonegative somas and dendrites; (3) co-existence of ENK/GABA-ir axon terminals and convergence of ENK- and GABA-ir terminals on one immunonegative soma or dendrite can also be observed. These results suggest that ENK should inhibit directly or excite indirectly (by blocking the inhibition of the GABAergic neurons) the gustatory neurons in the rNTS.
豚鼠的慢性吗啡治疗会在体外诱导孤束核的非特异性敏感性变化。
DOI：
--
发表时间：
1997
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Malanga,CJ;Meng,J;Fleming,WW;Taylor,DA
通讯作者：
Taylor,DA