Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide
Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide
复制标题
DOI：
10.1097/00006982-200506000-00017
复制
发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Ogura, Y
中科院分区：
文献类型：
--
作者：
Kato, A;Kimura, H;Ogura, Y
目的：目的：观察曲安奈德（TA）对激光诱导的大鼠脉络膜新生血管（CNV）的抑制作用。方法：采用激光光凝法诱导Brown-Norway雄性大鼠实验性CNV。实验眼接受2 mg（n=10）或0.5 mg（n=8）TA的后Tenon下给药。对照眼（n=10）接受等渗氯化钠溶液的后Tenon下给药。治疗后2周，通过荧光血管造影和组织病理学检查评估CNV。用高效液相色谱法测定眼后Tenon下给药后3、7天玻璃体、视网膜和脉络膜中TA的浓度。结果：与对照眼和0.5mg TA组相比，2 mg TA组荧光素渗漏明显减少（P
Purpose: To evaluate the inhibitory effect of triamcinolone acetonide (TA) on choroidal neovascularization (CNV) by posterior sub-Tenon administration using a laser-induced CNV model in the rat.Methods: Experimental CNV was induced by laser photocoagulation in Brown-Norway male rats. Experimental eyes received posterior sub-Tenon administration of either 2 mg (n=10) or 0.5 mg (n=8) of TA. Control eyes (n=10) received posterior sub-Tenon administration of isotonic sodium chloride solution. Two weeks after treatment, CNV was evaluated by fluorescein angiography and histopathological examination. Concentrations of TA in the vitreous, retina, and choroid were determined by high-performance liquid chromatography at 3 and 7 days after posterior sub-Tenon administration.Results: The eyes treated with 2 mg of TA showed statistically significant inhibition of fluorescein leakage by fluorescein angiography, as compared with control eyes and eyes treated with 0.5 mg of TA (P