Prevalence and Determinants of Hyperlipidemia in Moderate Altitude Areas of the Yunnan-Kweichow Plateau in Southwestern China
Prevalence and Determinants of Hyperlipidemia in Moderate Altitude Areas of the Yunnan-Kweichow Plateau in Southwestern China
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DOI：
10.1089/ham.2011.1037
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发表时间：
2012-03-01
影响因子：
2.1
通讯作者：
Ma, Jing
中科院分区：
文献类型：
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作者：
Deng, Bingjun;Luo, Tingguang;Ma, Jing
邓炳军，罗廷光，黄燕飞，沈天航，马晶。中国西南部云贵高原中等海拔地区高脂血症的患病率和决定因素。高Alt。医学生物学13：13-21。本研究的目的是确定高脂血症的患病率和影响因素，生活在中国西南部的云南-贵州高原的中等海拔地区的人群。我们随机招募了1415人参与这项研究。这些受试者接受了体格检查和关于他们日常生活习惯和饮食的全面问卷调查。此外，还收集了参与者的血液样本以评估血脂谱。我们发现49.3%的参与者（95%CI：46.7-51.9%）患有高脂血症。男性患病率为53.6%，女性患病率为44.7%，差异有显著性（P < 0.01）。高胆固醇血症的患病率为23.3%，高甘油三酯血症的患病率为34.1%。低HDL-C的患病率为17.5%，高LDL-C的患病率为9.0%。高脂血症的患病率也随着年龄的增长而增加，高TC、TG和LDL-C的患病率也是如此。与研究队列中血脂正常的受试者相比，高血脂受试者往往年龄较大，BMI和WHR较高（p < 0.05）。高血压受试者，无论男性还是女性，都倾向于经常外出就餐，消耗更多的动物性食物和酒精。此外，高血脂组男性比血脂正常组男性食用更多的咸食（p < 0.01）。血脂正常的男女受试者也更喜欢素食（p < 0.01）。年龄、饮酒、偏爱肉类和动物产品、经常外出就餐和BMI是女性高脂血症的主要决定因素，而在所研究的云贵高原亚群中，观察到咸食的流行与男性高脂血症有关（p < 0.05）。高血脂组的能量、蛋白质和脂肪的日平均摄入量均高于中国推荐营养素摄入量（RNI），而总脂肪、胆固醇和低膳食纤维的日平均摄入量均高于正常血脂组（p < 0.05）。结果表明，云贵高原地区男性高脂血症、高胆固醇血症、高甘油三酯血症、BMI和WHR增高的患病率较高，女性低HDL-C和高LDL-C的患病率略高。高脂血症的发病率也随着年龄的增长而增加，在我们的研究队列中，TC、TG、LDL-C和WHR异常的患病率也是如此。因此，高BMI、不健康的生活习惯和饮食偏好在高脂血症的发病中起着重要作用。
Deng, Bingjun, Tingguang Luo, Yanfei Huang, Tianhang Shen, Jing Ma. Prevalence and determinants of hyperlipidemia in moderate altitude areas of the Yunnan-Kweichow Plateau in Southwestern China. High Alt. Med. Biol. 13: 13-21.-The objective of the current study was to determine the prevalence and determinants of hyperlipidemia among the populations living at moderate altitude on the Yunnan-Kweichow Plateau in Southwestern China. We randomly recruited 1415 people for this study. These subjects underwent a physical examination and a comprehensive questionnaire regarding their daily habits and diets. Furthermore, blood samples from the participants were collected for assessing the lipid profile. We found that 49.3% of participants (95% CI: 46.7-51.9%) suffered from hyperlipidemia. The prevalence in men was significantly higher than that in women (53.6% vs. 44.7%, p < 0.01). The prevalence of hypercholesterolemia was 23.3% and of hypertriglyceridemia was 34.1%. Low HDL-C showed a prevalence of 17.5% and high LDL-C of 9.0%. The prevalence of hyperlipidemia also increased with age, as did the prevalence of high TC, TG, and LDL-C. Hyperlipidemic subjects tended to be older and have a higher BMI and WHR than the normolipidemic subjects in the study cohort (p < 0.05). The hyperlipidemic subjects, both men and women, tended to dine out often and consume more animal-based foods and alcohol. In addition, the hyperlipidemic men in our cohort consumed more salted food then their normolipidemic counterparts (p < 0.01). Normolipidemic subjects of both sexes were also found to prefer a vegetarian diet (p < 0.01). Age, alcohol consumption, a preference for meat and animal products, regular dining out, and BMI were found to be the main determinants of hyperlipidemia in women, whereas a prevalence of salted food was observed to be related to hyperlipidemia in men from the Yunnan-Kweichow Plateau subpopulation under study (p < 0.05). The average daily energy, and protein and fat intakes of the sampled subjects were also higher than the levels set by the Chinese Recommendation Nutrient Intakes (RNI), while hyperlipidemic subjects had an even higher average daily intake of total fat, cholesterol, and lower dietary fiber compared with the normolipidemic subjects in the study group (p < 0.05). In conclusion, this study reveals a higher prevalence of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, increased BMI and WHR values in men, as well as a slightly higher prevalence of low HDL-C and high LDL-C in women from Yunnan-Kweichow Plateau. The incidence of hyperlipidemia also increased with age, as did the prevalence of an abnormal TC, TG, LDL-C, and WHR in our study cohort. A high BMI, and less healthy living habits and dietary preferences thus play significant roles in the onset of hyperlipidemia.