The effect of folate-appended methyl-β-cyclodextrin increases on survival rates in a peritoneal dissemination mouse models of human ovarian cancer
The effect of folate-appended methyl-β-cyclodextrin increases on survival rates in a peritoneal dissemination mouse models of human ovarian cancer
复制标题
添加叶酸的甲基-β-环糊精可提高人类卵巢癌腹膜播散小鼠模型的生存率
DOI：
10.1007/s10847-021-01109-y
复制
发表时间：
2022
影响因子：
2.3
通讯作者：
K. Motoyama
中科院分区：
文献类型：
--
作者：
R. Onodera;A. Sakai;A. Tokuda;T. Higashi;K. Motoyama
在妇科癌症中，已知卵巢癌对化疗高度敏感。然而，它通常在晚期被检测到，因为它表现出很少的早期症状，因此，患者往往表现出不良预后。因此，需要开发用于治疗晚期癌症的新抗癌剂。叶酸修饰的甲基-β-环糊精（FA-M-β-CyD）是一种具有选择性抗肿瘤活性的新型抗肿瘤药物。然而，FA-M-β-CyD在卵巢癌中的抗肿瘤作用尚不清楚。因此，在本研究中，我们研究了FA-M-β-CyD在卵巢癌中的抗肿瘤作用。FA-M-β-CyD对还原型叶酸载体（RFC）阳性的人卵巢癌ES-2细胞株具有良好的细胞毒活性。我们发现FA-M-β-CyD在ES-2（RFC+）细胞中的细胞毒活性不太可能是由线粒体膜电位降低引发的凋亡的结果。此外，FA-M-β-CyD还能延长荷ES-2（RFC+）细胞的BALB/c裸鼠的存活时间。这些结果表明FA-M-β-CyD作为治疗转移性卵巢癌的抗肿瘤剂的潜力。
Among gynaecological cancers, ovarian cancer is known to be highly sensitive to chemotherapy. However, it is often detected at an advanced stage since it exhibits few early symptoms, and therefore, patients tend to show poor prognosis. Therefore, the development of new anticancer agents for the treatment advanced stage cancers is required. We previously reported that folic acid-modified methyl-β-cyclodextrin (FA-M-β-CyD) is a promising anticancer agent that exhibits selective antitumor activity in cancers cells. However, the antitumor effect of FA-M-β-CyD in ovarian cancer is not known. Therefore, in this study, we investigated the antitumor effect of FA-M-β-CyD in ovarian cancer. FA-M-β-CyD showed excellent cytotoxic activity in the reduced folate carrier (RFC) positive human ovarian cancer ES-2 cells line. We found that the cytotoxic activity of FA-M-β-CyD in ES-2 (RFC+) cells is unlikely to be a result of apoptosis triggered by a decrease in mitochondrial membrane potential. Moreover, FA-M-β-CyD prolonged the survival of BALB/c nude mice bearing ES-2 (RFC+) cells. These results suggest the potential of FA-M-β-CyD as an antitumor agent for treatment of metastatic ovarian cancer.
登录
查看更多内容
影响因子：
3.7
作者：
Siu MK;Kong DS;Chan HY;Wong ES;Ip PP;Jiang L;Ngan HY;Le XF;Cheung AN
通讯作者：
Cheung AN
影响因子：
5.3
作者：
Maeda, Yuki;Motoyama, Keiichi;Arima, Hidetoshi
通讯作者：
Arima, Hidetoshi
DOI：
10.1200/jco.2003.01.066
发表时间：
2003
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
W. Mcguire
通讯作者：
W. Mcguire
特定脂质的变化调节 BAX 诱导的线粒体通透性转变
DOI：
--
发表时间：
2007
期刊：
The FEBS Journal
影响因子：
--
作者：
E. Martínez;N. García;F. Correa;M. Franco;C. Zazueta
通讯作者：
C. Zazueta