Developmental Gene Regulation by an Ancient Intercellular Communication System in Social Amoebae
Developmental Gene Regulation by an Ancient Intercellular Communication System in Social Amoebae
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DOI：
10.1016/j.protis.2010.12.002
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发表时间：
2012-01-01
期刊：
影响因子：
2.5
通讯作者：
Winckler, Thomas
中科院分区：
文献类型：
--
作者：
Asghar, Asma;Groth, Marco;Winckler, Thomas
社会阿米巴(Dictyostelia)使用类似群体感应的通信系统来协调从单细胞到多细胞的周期性转变。Dictyostelia的单系进化为研究这种细胞间通讯系统的起源和适应性进化提供了一个独特的机会。我们确定，聚集能力细胞对细胞间信使Glorin的反应能力发生在Dictyostelia的最古老的分类群中。我们使用Illumina测序技术证明了Glorin在从营养生长到聚集的转变过程中介导了基因表达的快速变化。我们的结论是，在社会阿米巴的多细胞进化中，基于多肽的通讯是最古老的细胞间信号传递形式，但在社会阿米巴的单系进化过程中，它已被其他通讯系统反复取代。Glorin通讯与群体感应有相似之处，因为分子扩散到场内，刺激感受性细胞中的基因表达，并协调整个群体的反应。(C)2011年爱思唯尔股份有限公司。版权所有。
The social amoebae (Dictyostelia) use quorum sensing-like communication systems to coordinate the periodic transition from uni- to multicellularity. The monophyletic descent of the Dictyostelia provides a unique opportunity to study the origin and adaptive evolution of such intercellular communication systems. We determined that the ability of aggregation-competent cells to respond to the intercellular messenger glorin occurred in the most ancient taxa of the Dictyostelia. We show using Illumina sequencing technology that glorin mediates rapid changes in gene expression at the transition from vegetative growth to aggregation. We conclude that peptide-based communication is the most ancient form of intercellular signaling in the evolution of multicellularity in the social amoebae, but has been repeatedly replaced by other communication systems during the monophyletic evolution of the social amoebae. Glorin communication has parallels with quorum sensing in that the molecule diffuses into the field, stimulates gene expression in receptive cells and coordinates a population-wide response. (C) 2011 Elsevier GmbH. All rights reserved.