Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder
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DOI：
10.1002/nbm.1512
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发表时间：
2010-07-01
影响因子：
2.9
通讯作者：
Shungu, Dikoma C.
中科院分区：
文献类型：
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作者：
Murrough, James W.;Mao, Xiangling;Shungu, Dikoma C.
慢性疲劳综合征（CFS）是一种以疲劳、注意力不集中和肌肉骨骼疼痛为特征的复杂疾病，由于其症状与情绪和焦虑障碍重叠，经常被误诊为精神疾病。我们先前使用质子磁共振光谱成像（H-1 MRSI）测量了CFS、广泛性焦虑障碍（GAD）和健康对照受试者的主要脑代谢物水平，发现CFS患者的脑脊液（SF）乳酸水平明显高于其他两组。在本研究中，我们试图通过比较17名CFS患者与19名健康志愿者和21名重度抑郁症（MDD）患者的心室乳酸水平来评估这一观察结果对CFS的特异性。重度抑郁症（MDD）与GAD一样，是一种与CFS有显著症状重叠的神经精神疾病。与健康志愿者相比，CFS患者心室（SF）乳酸显著升高，与我们之前研究的主要结果重复。MDD患者的心室乳酸测量与CFS或健康志愿者没有差异。我们发现心室（SF）乳酸与精神疲劳严重程度之间存在显著相关性，这是CFS组特有的。在一项探索性分析中，我们没有发现与MDD或健康对照相比，CFS中氨基酸神经递质γ -氨基丁酸（GABA）和谷氨酸+谷氨酰胺（Glx）水平改变的证据。为了进一步明确CFS和MDD中神经代谢异常的敏感性和特异性，未来有必要进行更大样本量和特征明确的人群的H-1 MRS研究。版权所有John Wiley & Sons， Ltd。
Chronic fatigue syndrome (CFS), a complex illness characterized by fatigue, impaired concentration, and musculoskeletal pain, is often misdiagnosed as a psychiatric illness due to the overlap of its symptoms with mood and anxiety disorders. Using proton magnetic resonance spectroscopic imaging (H-1 MRSI), we previously measured levels of the major brain metabolites in CFS, in generalized anxiety disorder (GAD), and in healthy control subjects, and found significantly higher levels of ventricular cerebrospinal fluid ((SF) lactate in CFS compared to the other two groups. In the present study, we sought to assess the specificity of this observation for CFS by comparing ventricular lactate levels in a new cohort of 17 CFS subjects with those in 19 healthy volunteers and in 21 subjects with major depressive disorder (MDD), which, like GAD, is a neuropsychiatric disorder that has significant symptom overlap with CFS. Ventricular (SF lactate was significantly elevated in CFS compared to healthy volunteers, replicating the major result of our previous study. Ventricular lactate measures in MDD did not differ from those in either CFS or healthy volunteers. We found a significant correlation between ventricular (SF lactate and severity of mental fatigue that was specific to the CFS group. In an exploratory analysis, we did not find evidence for altered levels of the amino acid neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate + glutamine ('Glx'), in CFS compared to MDD or healthy controls. Future H-1 MRS studies with larger sample sizes and well-characterized populations will be necessary to further clarify the sensitivity and specificity of neurometabolic abnormalities in CFS and MDD. Copyright (C) 2010 John Wiley & Sons, Ltd.