Rapid acquisition of auditory subcortical steady state responses using multichannel recordings.
Rapid acquisition of auditory subcortical steady state responses using multichannel recordings.
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DOI：
10.1016/j.clinph.2014.01.011
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Shinn-Cunningham BG
中科院分区：
文献类型：
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作者：
Bharadwaj HM;Shinn-Cunningham BG
听觉皮层下稳态反应（SSSR），也称为频率跟随反应（FFR），提供了一种非侵入性的测量相位锁定的神经响应声学和耳蜗诱导的周期性。SSSR已用于临床和听觉功能的基础神经生理学研究。SSSR数据采集通常涉及每种刺激类型的数千次呈现，有时在两个极性中，每个受试者的采集时间通常超过一个小时。在这里，我们提出了一种新的方法，以减少数据采集时间显着。由于SSSR的来源比主要噪音源（即背景自发皮质活动）更深，因此SSSR在头皮上的变化比噪音更平稳。我们利用这一属性，并提取SSSR有效地，使用多通道录音和复杂的跨通道谱密度矩阵的特征分解。与传统的单通道方法相比，我们提出的方法产生的SNR改善超过了3倍。这是可能的，以减少SSSR的数据采集时间显着与我们的方法。所提出的方法允许SSSRs被记录在一个单一的会话内的几个刺激条件，也使得它有可能获得SSSRs和皮层EEG响应，而不增加会话长度。
Auditory subcortical steady state responses (SSSRs), also known as frequency following responses (FFRs), provide a non-invasive measure of phase-locked neural responses to acoustic and cochlear-induced periodicities. SSSRs have been used both clinically and in basic neurophysiological investigation of auditory function. SSSR data acquisition typically involves thousands of presentations of each stimulus type, sometimes in two polarities, with acquisition times often exceeding an hour per subject. Here, we present a novel approach to reduce the data acquisition times significantly. Because the sources of the SSSR are deep compared to the primary noise sources, namely background spontaneous cortical activity, the SSSR varies more smoothly over the scalp than the noise. We exploit this property and extract SSSRs efficiently, using multichannel recordings and an eigendecomposition of the complex cross-channel spectral density matrix. Our proposed method yields SNR improvement exceeding a factor of 3 compared to traditional single-channel methods. It is possible to reduce data acquisition times for SSSRs significantly with our approach. The proposed method allows SSSRs to be recorded for several stimulus conditions within a single session and also makes it possible to acquire both SSSRs and cortical EEG responses without increasing the session length.