Increased epidermal growth factor levels in human milk of mothers with extremely premature infants
Increased epidermal growth factor levels in human milk of mothers with extremely premature infants
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DOI：
10.1203/01.pdr.0000065729.74325.71
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发表时间：
2003-07-01
影响因子：
3.6
通讯作者：
Schanler, RJ
中科院分区：
文献类型：
--
作者：
Dvorak, B;Fituch, CC;Schanler, RJ
母乳是大多数新生儿在生命最初几周内营养和生长促进物质的主要来源。表皮生长因子（EGF）和转化生长因子-α（TGF-α）是存在于人乳中的营养肽，对受损的胃肠道粘膜具有显著的愈合作用。新生儿胎龄的降低与发生胃肠道疾病的风险增加有关，与配方奶粉相比，母乳对这些疾病提供了更好的保护。本研究的目的是评估EGF和TGF-α在母乳中的浓度，这些母乳是从极早产儿、早产儿和足月儿的母亲那里收集的。在产后第一、第二和第四周结束时，从三个胎龄组中的一个胎龄组中出生的婴儿的每个母亲收集乳汁样品：极早产（23-27周，n = 16）、早产（32-36周，n = 16）和足月（38-42周，n = 15）。牛奶浓度。EGF和TGF-α的定量与同源RIA在牛奶的水性部分。在哺乳期的第一个月，早产儿组（23-27周）母乳中EGF的浓度显著高于早产儿和足月儿组。在人乳TGF-α中观察到类似的模式;然而，乳汁TGF-α水平低于EGF。总之，我们发现极早产儿母亲的母乳中EGF和TGF-α浓度较高。这些数据可能表明了乳源性EGF和TGF-α对极早产儿发育的潜在重要性。
Maternal milk is the major source of nutrients and growth-promoting substances in the first weeks of life for the majority of neonates. Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are trophic peptides present in human milk with significant healing effects on injured gastrointestinal mucosa. Decreasing gestational age of neonates is associated with higher risk of developing gastrointestinal disorders, and human milk provides better protection against these diseases compared with formula. The aim of this study was to evaluate the concentrations of EGF and TGF-alpha in human milk collected from mothers with infants born: extremely preterm, preterm, and full term. Milk samples were collected at the end of first, second, and fourth week postpartum from each mother of infants born in one of the three gestational age groups: extremely preterm (23-27 wk, n = 16), preterm (32-36 wk, n = 16), and full term (38-42 wk, n = 15). Milk concentrations of. EGF and TGF-alpha were quantified with a homologous RIA in the milk aqueous fraction. Concentrations of EGF in human milk from the extremely pre-term group (23-27 wk) were significantly higher compared with values from the preterm and full-term groups throughout the first month of lactation. A similar pattern was observed with human milk TGF-alpha; however, milk TGF-alpha levels were lower than EGF. In conclusion, we have found higher concentrations of EGF and TGF-alpha in human milk of mothers with extremely preterm babies. These data may indicate the potential importance of milk-borne EGF and TGF-alpha for the development of extremely premature infants.