ROLE OF THE DUODENUM IN THE CONTROL OF CANINE GASTROINTESTINAL MOTILITY
ROLE OF THE DUODENUM IN THE CONTROL OF CANINE GASTROINTESTINAL MOTILITY
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DOI：
10.1016/0016-5085(88)90232-6
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发表时间：
1988-03-01
期刊：
影响因子：
29.4
通讯作者：
SARR, MG
中科院分区：
文献类型：
--
作者：
TANAKA, M;SARR, MG
本研究旨在确定十二指肠在控制犬胃和小肠消化间迁移运动复合体中的作用。研究了4只犬全十二指肠切除胆管和胰管再植前后的运动规律。十二指肠切除术前，血浆胃动素和胰多肽浓度随移行运动复合体周期性变化。在十二指肠切除术后，4只狗中有3只在禁食期间胃内的迁移运动复合体消失。另一只狗表现出胃收缩活动的间歇性周期性增加，但具有明显的异常特征和不规则的间隔。4只狗的空肠迁移运动复群在十二指肠切除术后继续循环，但平均周期短于十二指肠切除术前（83 min vs. 147 min, p < 0.01）。十二指肠切除术消除了血浆胃动素和胰多肽的循环变化，降低了各期血浆胃动素和胰多肽的浓度。本研究提示十二指肠在胃迁移运动复合体的启动和消化间胃肠运动活动的协调中起重要作用，可能是通过胃动素的释放。
This study was designed to determine the role of the duodenum in controlling the interdigestive migrating motor complex of the canine stomach the small intestine. The motility patterns of 4 dogs were studied before and after resection of the entire duodenum with reimplantation of bile and pancreatic ducts. Before duodenectomy, plasma concentrations of motilin and pancreatic polypeptide varied cyclically with the migrating motor complex. After duodenectomy, the migrating motor complex was abolished in the stomach in 3 of the 4 dogs during fasting. The other dog demonstrated what appeared to be an intermittent cyclic increase in gastric contractile activity, but with markedly abnormal characteristics and at irregular intervals. The jejunal migrating motor complex continued to cycle after duodenectomy in all 4 dogs, but the mean period was shorter than before duodenectomy (83 min vs. 147 min, p < 0.01). Duodenectomy abolished the cyclic variations of plasma motilin and pancreatic polypeptide and lowered the concentration of both peptides during all phases. This study suggests that the duodenum plays an important role in the initiation of the gastric migrating motor complex and in the coordination of interdigestive gastrointetinal motor activity, possibly by the release of motilin.