Sex- and hemisphere-related influences on the neurobiology of emotionally influenced memory
Sex- and hemisphere-related influences on the neurobiology of emotionally influenced memory
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DOI：
10.1016/j.pnpbp.2003.09.019
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发表时间：
2003-12-01
影响因子：
5.6
通讯作者：
Cahill, L
中科院分区：
文献类型：
--
作者：
Cahill, L
最近的研究结果开始揭示性别和大脑半球对情绪影响记忆的神经生物学的明显影响。在这篇文章中，我首先提供了一个简短的，一般性的概述与性别有关的影响大脑和认知。接下来，我将描述我的实验室和其他实验室的最新发现，这些发现证明了性对神经机制的影响，这些神经机制是情绪影响外显回忆情绪唤起事件的基础。人类杏仁核在记忆中对情绪唤起事件的半球参与和β-肾上腺素能阻滞对情绪事件记忆的损害作用都表现出性别相关差异。我假设这两种效应都与杏仁核对同侧半球功能的调节作用有关。具体来说，我假设，右半球杏仁核调制右半球处理的全球/中央方面的情况（男性的效果更明显），而左半球杏仁核调制左半球处理的更多的本地/精细细节方面的情况（女性的效果更明显）。更一般地说，这些研究结果表明，性别和大脑半球对情绪影响记忆的相互影响比迄今为止广泛认识的更明显。(C)2003年爱思唯尔公司All rights reserved.
Recent findings are beginning to reveal apparently pronounced influences of both sex and cerebral hemisphere on the neurobiology of emotionally influenced memory. In this article, I first provide a brief, general overview of sex-related influences on brain and cognition. I next describe recent findings from my laboratory and others demonstrating sex-related influences on neural mechanisms underlying emotionally influenced explicit recall of emotionally arousing events. Both the hemispheric involvement of the human amygdala in memory for emotionally arousing events and the impairing effect of beta-adrenergic blockade on memory for emotional events, exhibit sex-related differences. I hypothesize that both of these effects relate to a modulatory influence of each amygdala on ipsilateral hemispheric function. Specifically, I hypothesize that the right hemisphere amygdala modulates right hemispheric processing of global/central aspects of a situation (an effect more pronounced in males), while the left hemisphere amygdala modulates left hemispheric processing of more local/fine detail aspects of a situation (an effect more pronounced in females). More generally, these findings presented here suggest that the interacting influences of sex and cerebral hemisphere on emotionally influenced memory are more pronounced than has been widely appreciated to date. (C) 2003 Elsevier Inc. All rights reserved.