Novel channel structure of bile acid-guest inclusion complex formed between ursodeoxycholic acid and phenanthrene.
Novel channel structure of bile acid-guest inclusion complex formed between ursodeoxycholic acid and phenanthrene.
复制标题
熊去氧胆酸与菲形成的胆汁酸-客体包合物的新型通道结构。
DOI：
10.1248/cpb.51.227
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发表时间：
2003
影响因子：
1.7
通讯作者：
Keiji. Yamamoto
中科院分区：
文献类型：
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作者：
T. Fukami;K. Yamaguchi;Y. Tozuka;K. Moribe;T. Oguchi;Keiji. Yamamoto
测定了熊去氧胆酸（UDCA）与菲包合物的晶体结构。UDCA分子形成氢键网络，提供沿b轴的通道结构，菲分子以1:1摩尔比的化学计量量被安置在腔内。udca -菲配合物的通道结构与先前报道的脱氧胆酸（DCA）和胆酸（CA）包合物的通道结构明显不同。由于具有网状的氢键网络，UDCA的通道框架比DCA和CA具有更小的柔韧性。在固态荧光测量中可以清楚地观察到菲分子状态的差异。
The crystal structure of inclusion complex between ursodeoxycholic acid (UDCA), and phenanthrene has been determined. UDCA molecules formed hydrogen bond network to provide the channel structure along b axis, and phenanthrene molecules were accommodated in the cavity with a stoichiometry of 1 : 1 molar ratio. The channel structure observed in the UDCA-phenanthrene complex was significantly different from that of inclusion complex previously reported for deoxycholic acid (DCA) and cholic acid (CA). Because of the mesh-like hydrogen bond network, channel framework of UDCA could have less flexibility than that of DCA and CA. The difference of molecular state of phenanthrene was clearly observed in solid-state fluorescence measurement.
K.Nakano、K.Sada、Y.Kurozumi 和 M.Miyata：“主腔填充系数在开放主框架异构化中的重要性：单取代苯胆酸包合物晶体中的客体尺寸依赖性异构化”Chem。
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