Nodal involvement in bladder cancer cases treated with radical cystectomy: Incidence and prognosis
Nodal involvement in bladder cancer cases treated with radical cystectomy: Incidence and prognosis
复制标题
DOI：
10.1097/01.ju.0000132132.72351.4c
复制
发表时间：
2004-07-01
影响因子：
6.6
通讯作者：
Ghoneim, MA
中科院分区：
文献类型：
--
作者：
Abdel-Latif, M;Abol-Enein, H;Ghoneim, MA
目的：我们研究的因素，促进淋巴结转移的发病率和特点的生存预测的情况下，根治性cyclization.Materials和方法：我们回顾性研究了418例膀胱癌根治性cyclizationandbilateral肾盂内淋巴结清扫术。淋巴结受累的发生率与一些患者和肿瘤特征相关。涉及的节点的数量也与检索到的节点的数量相关。结果：418例中，110例（26.3%）有淋巴结转移。每例患者采集的平均淋巴结数量+/- SE为17.9 +/- 6.7。每个受累病例的平均阳性淋巴结数量为4.1 +/- 5.4。检索到的节点数和阳性节点数之间的相关性较弱（r = 0.4）。肿瘤pT分期、分级、淋巴管侵犯是淋巴结转移的独立因素。淋巴结阳性病例的3年无病生存率为37.8% ± 4.8%。两个因素有一个独立的影响生存在淋巴结阳性的情况下，即pT阶段和阳性nodes.Conclusions的数量：肿瘤pT阶段和级别，淋巴管浸润独立影响淋巴结受累的发病率。检索到的节点数和阳性节点数之间存在弱相关性。pT N+病例的生存率与pT分期和受累淋巴结数目有关。有必要进行一项前瞻性研究，对取出的淋巴结进行解剖标测，以确定使用Cyberstimulus进行淋巴结切除术的最佳范围。
Purpose: We studied the factors that promote the incidence of nodal metastasis and characterized survival predictions in cases treated with radical cystectomy.Materials and Methods: We retrospectively studied 418 bladder cancer cases treated with radical cystectomy and bilateral endopelvic lymphadenectomy. The incidence of nodal involvement was correlated with several patient and tumor characteristics. The number of involved nodes was also correlated with the number of retrieved nodes. Finally, survival in node positive cases was correlated with some select pathological features.Results: Of the 418 cases nodal involvement was reported in 110 (26.3%). The mean number of harvested nodes per patient +/- SE was 17.9 +/- 6.7. The mean number of positive nodes per involved case was 4.1 +/- 5.4. A weak correlation between the number of retrieved nodes and number of positive nodes was noted (r = 0.4). Tumor pT stage and grade, and lymphovascular invasion were independent factors promoting the incidence of nodal involvement. Three-year disease-free survival in node positive cases was 37.8% +/- 4.8%. Two factors had an independent impact on survival in node positive cases, namely pT stage and the number of positive nodes.Conclusions: Tumor pT stage and grade, and lymphovascular invasion independently influence the incidence of lymph node involvement. There was a weak correlation between the number of retrieved nodes and number of positive nodes. The survival probability in pT N+ cases depended on pT stage and the number of involved nodes. A prospective study with anatomical mapping of retrieved nodes is necessary to define the optimal extent of lymphadenectomy with cystectomy.