Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans
Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans
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DOI：
10.1053/gast.1996.v110.pm8566578
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发表时间：
1996-02-01
期刊：
影响因子：
29.4
通讯作者：
Hatakeyama, K
中科院分区：
文献类型：
--
作者：
Kanda, T;Fujii, H;Hatakeyama, K
背景与目的：小肠急性缺血性疾病是一种致命性急症，目前尚无可靠的生化诊断方法。实验研究表明，大鼠肠脂肪酸结合蛋白(I-FABP)是反映肠缺血的血清标志物；本研究评价了人的同源物(人I-FABP)作为诊断急性肠缺血性疾病的血清标志物。方法：采用酶免疫法测定13例缺血性肠病患者(其中肠系膜梗死5例，绞窄性肠梗阻8例)、35例健康人和48例急性腹痛住院患者的血清I-FABP水平。结果：血清I-FABP水平
Background & Aims: Acute ischemic diseases of the small bower are lethal emergencies with no reliable diagnostic biochemical tests available. Experimental studies have suggested rat intestinal fatty acid-binding protein (I-FABP) as a serum marker reflecting bowel ischemia; the present study evaluates the human homologue (human I-FABP) as a serum marker for the diagnosis of acute ischemic diseases of the bowel. Methods: Enzyme immunoassay was applied to determine I-FABP levels in the sera of 96 subjects: 13 preoperative patients with ischemic bower diseases (5 cases of mesenteric infarction and 8 cases of strangulated obstruction of the small bowel), 35 healthy subjects, and 48 hospitalized patients with acute abdominal pain. Results: Serum I-FABP levels were