Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells.
Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells.
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小作用大影响：miRNA 作为癌症相关成纤维细胞和癌细胞之间交流的通讯者
DOI：
10.7150/ijbs.17680
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发表时间：
2017
影响因子：
9.2
通讯作者：
Ding K
中科院分区：
文献类型：
--
作者：
Wang Z;Tan Y;Yu W;Zheng S;Zhang S;Sun L;Ding K
癌症微环境由许多成分组成，这些成分可以支持癌细胞增殖、促进癌症进展并导致癌症治疗耐药。肿瘤微环境的主要成分是成纤维细胞、内皮细胞、免疫细胞以及细胞因子、趋化因子和细胞外基质（ECM），它们以肿瘤细胞为核心，相互交叉作用。其中，癌症相关成纤维细胞（CAF）通过分泌多种促炎因子，在促进癌症进展中发挥重要作用。 MicroRNA (miRNA) 是一种小型非编码 RNA，可负调节癌细胞和正常基质细胞中的蛋白质表达。癌症相关成纤维细胞中 miRNA 表达的变化可以由癌细胞和其他基质细胞诱导。这种变化可以通过直接相互作用或通过分泌的旁分泌因子甚至通过分泌的 miRNA 来产生。癌症相关成纤维细胞中失调的 miRNA 会增强 CAF 表型并协助其促进癌症的能力。探索 miRNA 在癌细胞和癌症微环境之间复杂通讯中的调节功能对于了解肿瘤进展过程很重要，并可能有助于开发新的治疗策略。这篇综述提供了有关 miRNA 在癌细胞和 CAF 之间相互作用中的相关性的最新研究进展的更新内容。我们将在最近的研究中描述 NF 和 CAF 差异表达的 miRNA、它们在调节成纤维细胞活化中的功能以及 CAF 中表达的 miRNA 作为癌症基质中的预后因素。我们还将讨论 miRNA 在 CAF 介导的癌症进展和转移、癌症代谢、癌症干细胞特性和化疗耐药性调节中的重要作用。
Cancer microenvironment is composed of numerous components that can support cancer cell proliferation, promote cancer progression and contribute to cancer treatment resistance. The major components of caner microenvironment are fibroblasts, endothelial cells, immune cells as well as cytokines, chemokines, and extracellular matrix (ECM) all of which surround tumor cells as the core and cross talk with each other. Among them, cancer-associated fibroblasts (CAFs) play an important role in promoting cancer progression by secreting various pro-inflammatory factors. MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate protein expression both in cancer cell and normal stromal cells. Changes of miRNAs expression in cancer-associated fibroblasts can be induced both by cancer cells and other stromal cells. This change can arise through direct interaction or by secreted paracrine factors or even by secreted miRNAs. The desregulated miRNAs in cancer-associated fibroblasts then enhance the CAFs phenotype and assist their cancer promotion ability. Explore the regulatory function of miRNAs in the complex communication between cancer cells and cancer microenvironment is important to understand the process of tumor progression and may help to develop new therapeutic strategies. This review provides an updated content of latest research advances about the relevance of miRNAs in the interaction between cancer cells and the CAFs. We will describe miRNAs which are differential expressed by NFs and CAFs, their function in regulating fibroblasts activation as well as miRNAs expressed in CAFs as prognostic factors in cancer stroma in recent studies. We will also discuss miRNA as an important player in CAFs mediated regulation of cancer progression and metastasis, cancer metabolism, cancer stem cell property and chemoresistance.