Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network - A sex-specific phenomenon
Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network - A sex-specific phenomenon
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DOI：
10.1001/archpsyc.62.10.1089
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发表时间：
2005-10-01
影响因子：
--
通讯作者：
Post, RM
中科院分区：
文献类型：
--
作者：
Suppes, T;Mintz, J;Post, RM
背景：抑郁症状与轻躁狂症状并存的患病率尚未量化。是否有一个更大的可能性，为妇女的经验，混合症状尚未解决。目的：以确定是否混合轻躁狂是观察到更频繁比欣快轻躁狂和是否存在性别效应在双相情感障碍患者。设置：学术研究设置在美国（4个网站）和欧洲（3个网站）。参与者：受试者在提供书面知情同意书后参加一项自然主义前瞻性研究。混合型轻躁狂定义为在一次特定访视时，Young躁狂评定量表评分为12分或更高，抑郁症状量表-临床医生-评分为15或更高的版本。鉴于这些量表中的项目部分重叠，完成了探索性分析，评估影响结果的仪器重叠。结果：在908名患者中，评估了7年内的14328次就诊。双相I型患者比双相11型患者更容易出现轻躁狂。在所有1044次轻躁狂症状患者的就诊中，57%符合混合轻躁狂的标准。处于轻躁狂状态的女性患抑郁症的可能性明显更大（P
Context: The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved.Objectives: To determine whether mixed hypomania is observed more frequently than euphoric hypomania and whether a sex effect exists in patients with bipolar disorder.Setting: Academic research settings in the United States (4 sites) and Europe (3 sites).Participants: Subjects were enrolled in a naturalistic prospective study after providing written informed consent.Main Outcome Measures: Mixed hypomania was defined at a given visit as a Young Mania Rating Scale score of 12 or higher and an Inventory of Depressive Symptomatology-Clinician-Rated Version score of 15 or higher. Given partial overlap of items from these scales, exploratory analyses were completed assessing instrument overlap affecting the findings.Results: In 908 patients, 14 328 visits over 7 years were evaluated. Patients with bipolar I disorder were significantly more likely to experience hypomania than those with bipolar 11 disorder. Of all 1044 visits by patients with hypomanic symptoms, 57% met criteria for mixed hypomania. The likelihood of depression was significantly greater for women during hypomania (P