One cell, two cell, red cell, blue cell: the persistence of a unicellular stage in multicellular life histories
One cell, two cell, red cell, blue cell: the persistence of a unicellular stage in multicellular life histories
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DOI：
10.1016/s0169-5347(97)01313-x
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发表时间：
1998-03-01
影响因子：
16.8
通讯作者：
Strathmann, RR
中科院分区：
文献类型：
--
作者：
Grosberg, RK;Strathmann, RR
随着发育生物学家在分子和遗传水平上越来越了解受精卵是如何长成成人的，人们很容易忘记，让他们有工作的现象，对进化生物学家来说，仍然是一个令人烦恼的问题：为什么单细胞阶段在多细胞生物的生活史中持续存在？有两种解释假设。一种解释是，单细胞阶段通过让每个都具有相同基因型的后代进行选择，清除了多细胞生物的有害突变。另一种解释是，单细胞阶段减少了生物体内基因不同的复制因子之间的利益冲突。
As developmental biologists come closer to understanding at the molecular and genetic levels how a zygote becomes an adult, it is easy to forget that the very phenomenon that gives them an occupation remains a vexing problem to evolutionary biologists: why do unicellular stages persist in life histories of multicellular organisms? There are two explanatory hypotheses. One is that a unicellular stage purges multicellular organisms of deleterious mutations by exposing offspring that are each uniformly of one genotype to selection. Another is that a one-cell stage reduces conflicts of interest among genetically different replicators within an organism.