Recognition of pathogen-associated molecular patterns by TLR family
Recognition of pathogen-associated molecular patterns by TLR family
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DOI：
10.1016/s0165-2478(02)00228-6
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发表时间：
2003-01-22
影响因子：
4.4
通讯作者：
Hemmi, H
中科院分区：
文献类型：
--
作者：
Akira, S;Hemmi, H
Toll样受体是一种I型跨膜蛋白，通过识别微生物的保守结构参与天然免疫。最近的研究表明，TLR3识别病毒产物dsRNA，而TLR9识别经常在细菌和病毒基因组中发现的未甲基化的CpG基序，但不识别脊椎动物。TLR7识别小分子合成免疫调节剂，包括咪喹莫特、R-848、洛索里宾和溴丙胺，所有这些都已经应用于或有望用于临床治疗病毒感染和癌症，浆细胞样树突状细胞表达TLR7和TLR9，并通过产生大量干扰素(干扰素-α)来响应TLR7和TLR9配体。这些结果表明，TLR3。TLR7和TLR9可能在检测和对抗病毒感染方面发挥重要作用。(C)2002年，爱思唯尔科学公司出版。
Toll-like receptors (TLRs) are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. Recent studies have shown that TLR3 recognizes dsRNA, a viral product, whereas TLR9 recognizes unmethylated CpG motifs frequently found in the genome of bacteria and viruses, but not vertebrates. TLR7 recognizes small synthetic immune modifiers including imiquimod, R-848, loxoribine, and bropirimine, all of which are already applied or promising for clinical use against viral infections and cancers, Plasmacytoid dendritic cells express TLR7 and TLR9, and respond to TLR7 and TLR9 ligands by producing a large amount of interferon (IFN-alpha). These results indicate that TLR3. TLR7 and TLR9 may play an important role in detecting and combating viral infections. (C) 2002 Published by Elsevier Science B.V.