Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes With Branch Retinal Vein Occlusion
Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes With Branch Retinal Vein Occlusion
复制标题
DOI：
10.1016/j.ajo.2016.03.033
复制
发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Hsu, Jason
中科院分区：
文献类型：
--
作者：
Samara, Wasim A.;Shahlaee, Abtin;Hsu, Jason
目的：利用光学相干断层扫描血管造影（OCTA）测量视网膜分支静脉闭塞（BRVO）患者视网膜深层和浅表血管网络的血管密度和中央凹无血管区（FAZ）面积。设计：回顾性观察性病例系列。方法：纳入单侧BRVO累及黄斑的患者。对BRVO及伴眼行OCTA。测量所有眼的黄斑血管密度、faz面积和中央凹厚度。结果：17例患者17只眼符合纳入标准。BRVO眼在整个扫描中测量的平均总血管密度在浅表网络（分别为48.07%对52.60%,P < 0.001）和深部网络（分别为52.60%对57.67%,P < 0.001）中均低于其他眼。在这两个网络中，受影响的BRVO区域的密度低于同一只眼睛和另一只眼睛中未受影响的区域（P < .001）。在深度网络中，BRVO眼未受影响区域的密度低于同眼相应区域的密度（分别为58.87%和61.65%,P = 0.04）。最小分辨角（logMAR）视力的对数与表层网络（r = -0.40, P = 0.02）和深层网络（r = -0.38, P = 0.03）的总体密度呈负相关。BRVO眼的平均FAZ面积仅在深度网络水平上显著低于其他眼(分别为0.519 mm(2)和0.410 mm(2))；P = .02)，与logMAR呈正相关（r = 0.34, P = .04）。结论：在BRVO的眼睛中，定量OCTA测量证实浅血管网和深血管网的血管密度下降。此外，血管密度和FAZ面积似乎与视觉功能有关。(C) 2016 Elsevier Inc.版权所有。
PURPOSE: To measure the vascular density and foveal avascular zone (FAZ) area in the deep and superficial retinal vascular networks using optical coherence tomography angiography (OCTA) in patients with branch retinal vein occlusion (BRVO).DESIGN: Retrospective observational case series.METHODS: Patients with unilateral BRVO involving the macula were enrolled. OCTA was performed on the BRVO and fellow eyes. Macular vascular density, FAZ-area, and foveal thickness were measured in all eyes.RESULTS: Seventeen eyes of 17 patients met inclusion criteria. The mean overall vascular density measured in the entire scan was lower in BRVO eyes compared to fellow eyes in both the superficial (48.07% vs 52.60%, respectively; P < .001) and deep (52.60% vs 57.67%, respectively; P < .001) networks. In both networks, the density was lower in the affected BRVO sector compared to the unaffected sector in the same eye and in the fellow eye (P < .001). In the deep network, the density was lower in the unaffected sector of the BRVO eye compared with the corresponding sector in the fellow eye (58.87% vs 61.65%, respectively; P = .04). A negative correlation was found between the logarithm of the minimal angle of resolution (logMAR) visual acuity and the overall density in superficial (r = -0.40, P = .02) and deep (r = -0.38, P = .03) networks. The mean FAZ area in BRVO eyes was significantly lower only at the level of the deep network when compared to the fellow eyes.(0.519 mm(2) vs 0.410 mm(2), respectively; P = .02) and correlated positively with logMAR (r = 0.34, P = .04).CONCLUSION: In eyes with BRVO, quantitative OCTA measurements confirm decreased vascular density in both the superficial and deep vascular networks. Moreover, vascular density and FAZ area appear to correlate with visual function. (C) 2016 Elsevier Inc. All rights reserved.