Maternal residential proximity to chlorinated solvent emissions and birth defects in offspring: a case-control study.
Maternal residential proximity to chlorinated solvent emissions and birth defects in offspring: a case-control study.
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DOI：
10.1186/1476-069x-13-96
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发表时间：
2014-11-19
期刊：
影响因子：
--
通讯作者：
Langlois PH
中科院分区：
文献类型：
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作者：
Brender JD;Shinde MU;Zhan FB;Gong X;Langlois PH
一些研究指出，母亲在职业上接触氯化溶剂与后代的出生缺陷之间存在关联，但缺乏关于这些溶剂的工业空气排放对出生缺陷的潜在影响的数据。利用德克萨斯州出生缺陷登记处1996-2008年出生的数据，我们研究了60，613例病例母亲和244，927例对照母亲的母亲居住地接近工业空气中释放的氯化溶剂与后代出生缺陷之间的关系。母亲的住宅暴露于溶剂排放估计的指标，考虑到住宅距离工业源和化学品的年度释放量。Logistic回归用于生成14种氯化溶剂排放物附近住宅与选定出生缺陷（包括神经管、唇裂、肢体缺陷和先天性心脏缺陷）之间关联的比值比和95%置信区间。所有风险估计值均根据分娩年份和产妇年龄、教育、种族/民族和居住的公共卫生区域进行调整。相对于暴露风险值为0，神经管缺陷与母亲住宅暴露相关（接触风险值>0）接触几种氯化溶剂，特别是四氯化碳（校正比值比[aOR] 1.42，95%置信区间[CI] 1.09，1.86）;氯仿（aOR 1.40，95% CI 1.04，1.87）;氯乙烷（aOR 1.39，95% CI 1.08，1.79）; 1，1，2-三氯乙烷（aOR 1.56，95% CI 1.11，2.18）;和1，2，3-三氯丙烷（aOR 1.49，95% CI 1.08，2.06）。一些氯化溶剂与唇裂、肢体缺陷和先天性心脏缺陷之间也存在显著关联。我们观察到一些排放物与35岁或35岁以上母亲的后代的神经管，口裂和心脏缺陷之间存在更强的联系，例如脊柱裂与四氯化碳（aOR 2.49，95% CI 1.09，5.72），腭裂伴1，2-二氯乙烷（aOR 1.93，95%1.05，3.54），唇裂伴或不伴腭裂与氯乙烷（aOR 1.81，95%CI 1.06，3.07）和三氯乙烯引起的阻塞性心脏缺损（aOR 1.43，95%CI 1.08，1.88）。这些研究结果表明，产妇住宅接近工业排放的氯化溶剂可能与选定的出生缺陷的后代，特别是在老年母亲。
Some studies have noted an association between maternal occupational exposures to chlorinated solvents and birth defects in offspring, but data are lacking on the potential impact of industrial air emissions of these solvents on birth defects. With data from the Texas Birth Defects Registry for births occurring in 1996–2008, we examined the relation between maternal residential proximity to industrial air releases of chlorinated solvents and birth defects in offspring of 60,613 case-mothers and 244,927 control-mothers. Maternal residential exposures to solvent emissions were estimated with metrics that took into account residential distances to industrial sources and annual amounts of chemicals released. Logistic regression was used to generate odds ratios and 95% confidence intervals for the associations between residential proximity to emissions of 14 chlorinated solvents and selected birth defects, including neural tube, oral cleft, limb deficiency, and congenital heart defects. All risk estimates were adjusted for year of delivery and maternal age, education, race/ethnicity, and public health region of residence. Relative to exposure risk values of 0, neural tube defects were associated with maternal residential exposures (exposure risk values >0) to several types of chlorinated solvents, most notably carbon tetrachloride (adjusted odds ratio [aOR] 1.42, 95% confidence interval [CI] 1.09, 1.86); chloroform (aOR 1.40, 95% CI 1.04, 1.87); ethyl chloride (aOR 1.39, 95% CI 1.08, 1.79); 1,1,2-trichloroethane (aOR 1.56, 95% CI 1.11, 2.18); and 1,2,3-trichloropropane (aOR 1.49, 95% CI 1.08, 2.06). Significant associations were also noted between a few chlorinated solvents and oral cleft, limb deficiency, and congenital heart defects. We observed stronger associations between some emissions and neural tube, oral cleft, and heart defects in offspring of mothers 35 years or older, such as spina bifida with carbon tetrachloride (aOR 2.49, 95% CI 1.09, 5.72), cleft palate with 1,2-dichloroethane (aOR 1.93, 95% 1.05, 3.54), cleft lip with or without cleft palate with ethyl chloride (aOR 1.81, 95% CI 1.06, 3.07), and obstructive heart defects with trichloroethylene (aOR 1.43, 95% CI 1.08, 1.88). These findings suggest that maternal residential proximity to industrial emissions of chlorinated solvents might be associated with selected birth defects in offspring, especially among older mothers.